缩宫素在中枢神经系统疾病中的研究进展  

Research Progress of Oxytocin in Central Nervous System Diseases

作　　者：宋双双 沈旭日 刘福旺 侯雪芹 SONG Shuangshuang;SHEN Xuri;LIU Fuwang;HOU Xueqin(College of Pharmacy,Shandong First Medical University(Shandong Academy of Medical Sciences),Tai'an 271016,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)药学院,泰安271016

出　　处：《医药导报》2023年第5期696-701,共6页Herald of Medicine

基　　金：山东省重点研发项目(2019GSF108069);国家自然科学基金青年项目(81703901)。

摘　　要：缩宫素是一种肽类激素,由垂体后叶分泌,经下丘脑的室旁核和视上核合成。缩宫素具有促进妊娠子宫平滑肌收缩和乳腺肌上皮收缩(排乳)的功能。近年来,缩宫素与脑内缩宫素受体结合产生的生理作用在中枢神经系统疾病领域受到广泛关注。该文回顾并总结缩宫素在中枢神经系统疾病中的研究进展及缩宫素类似物的应用,以期为缩宫素临床应用及新药研究开发提供参考。Oxytocin(OT)is a peptide hormone secreted by the posterior pituitary gland and synthesized through the paraventricular nucleus and supraoptic nucleus of the hypothalamus.For a long time,it has been known that OT has the function of promoting the contraction of the smooth muscle of the uterus and the contraction of the myoepithelium of the mammary gland(lactation).In addition to the above two classical functions,the physiological effect of OT binding to oxytocin receptors in the brain has attracted wide attention in central nervous system diseases.This paper reviews and summarizes the research progress of OT in central nervous system diseases,and discusses the possible mechanism of OT,in order to provide a theoretical basis for the clinical application of OT and the development of new drugs.

关 键 词：缩宫素 缩宫素受体 中枢神经系统疾病 缩宫素类似物 

分 类 号：R984[医药卫生—药品] R969[医药卫生—药学]