女性糖尿病周围神经病变与单纯糖尿病患者的尿液菌群分布比较  

Urinary Microflora Distribution in Women with Diabetic Peripheral Neuropathy and Diabetes Alone

作　　者：陈贝贝 常红叶[1] CHEN Bei-bei;CHANG Hong-ye(The First Affiliated Hospital of Henan University,Henan Kaifeng 475000)

机构地区：[1]河南大学第一附属医院,河南开封475000

出　　处：《深圳中西医结合杂志》2023年第4期69-72,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：开封市科技发展计划项目(2104010)。

摘　　要：目的:比较女性糖尿病周围神经病变(DPN)与单纯2型糖尿病(T2DM)患者尿液菌群分布的差异。方法:选取河南大学第一附属医院2021年1月至2022年6月收治的68例女性T2DM患者,将其分为T2DM组和DPN组,每组34例。采集所有患者的尿液样本,进行菌群检测并比较菌群分布特征;检测并比较两组患者肾功能及尿常规结果。结果:DPN组患者T2DM病程、高血压、视网膜病变合并率、糖尿病化血红蛋白、血尿酸、尿蛋白定量、尿白蛋白/尿肌酐比(UACR)、支原体科相对丰度高于T2DM组,差异具有统计学意义(P<0.05),高密度脂蛋白胆固醇、丙酸杆菌科、蛭弧菌科、乳杆菌属、丙酸菌属、蛭弧菌属比例低于T2DM组,差异具有统计学意义(P<0.05);两组患者尿液病原菌分布比较,差异无统计学意义(P>0.05)。结论:女性DPN患者尿液中支原体科菌群相对丰度异常升高,其他菌群的相对丰度异常降低。Objective To compare the difference of urine flora distribution between female diabetic peripheral neuropathy(DPN)and type 2 diabetes mellitus(T2DM).Methods Sixty-eight female T2DM patients admitted to the First Affiliated Hospital of Henan University from January 2021 to June 2022 were selected and divided into T2DM group and DPN group,with 34 cases in each group.Urine samples were collected from all patients for flora detection and comparison of flora distribution characteristics.The results of renal function and urine routine were detected and compared between the two groups.Results The course of T2DM,morbidity of hypertension and retinopathy,diabetic hemoglobin,uric acid,urinary protein quantity,urinary microalbumin/urinary creatinine ratio(UACR)and relative abundance of mycoplasma in DPN group were higher than those in T2DM group,and the differences were statistically significant(P<0.05).The proportions of high-density lipoprotein,propionibacterium,Bdellovibrio,Lactobacillus,propionibacterium and Bdellovibrio were lower than those of T2DM group,and the difference was statistically significant(P<0.05).There was no significant difference in the distribution of pathogenic bacteria in urine between 2 groups(P>0.05).Conclusion The relative abundance of mycoplasma microflora in urine of female diabetic peripheral neuropathy patients was abnormally increased,while the relative abundance of other microflora was abnormally decreased.

关 键 词：2型糖尿病 糖尿病周围神经病变 尿液检验 菌群分布 女性 

分 类 号：R587[医药卫生—内分泌]