TP53诱导的糖酵解和凋亡调控因子在常见心血管疾病中的研究进展  

Research progress of TP53-induced glycolysis and apoptosis regulator in common cardiovascular diseases

作　　者：李姚娜 杨慧宇[1] Li Yaona;Yang Huiyu(Department of Cardiology,Second Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第二医院心内科,太原030000

出　　处：《中国医药》2023年第4期599-602,共4页China Medicine

基　　金：国家自然科学基金(81700407);山西省卫生健康委员会“四个一批”科技兴医创新计划(2022XM08)。

摘　　要：TP53诱导的糖酵解和凋亡调控因子(TIGAR)可以减少糖酵解并保护机体免受氧化应激,与呼吸系统、神经系统、消化系统及泌尿系统等多系统疾病之间存在密切关系。近年来研究显示,TIGAR与各心血管疾病,如心肌缺血再灌注损伤、糖尿病心肌病、动脉粥样硬化、心力衰竭之间也存在密切关系。本文就TIGAR结构、生理功能及在常见心血管疾病中的作用作一综述,为心血管疾病的防治提供新的潜在靶点。TP53-induced glycolysis and apoptosis regulator(TIGAR)can reduce glycolysis and protect the body from oxidative stress,which is closely related to multisystem diseases such as respiratory,nervous,digestive and urinary systems.In recent years,studies have shown that TIGAR is also closely related to various cardiovascular diseases,such as myocardial ischemia-reperfusion injury,diabetic cardiomyopathy,atherosclerosis and heart failure.This paper reviews the structure,physiological function and role of TIGAR in common cardiovascular diseases,so as to provide new potential targets for the prevention and treatment of cardiovascular diseases.

关 键 词：TP53诱导的糖酵解和凋亡调控因子 心肌缺血再灌注损伤 糖尿病心肌病 动脉粥样硬化 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]