利伐沙班抗凝治疗在改善高龄非瓣膜病房颤患者轻度认知功能障碍的有效性分析  

Analysis of the Effectiveness of Rivaroxaban Anticoagulation Therapy in Improving Mild Cognitive Dysfunction in Elderly Patients with Nonvalvular Atrial Fibrillation

作　　者：刘小宇[1] 马波 刘赵阳 LIU Xiaoyu;MA Bo;LIU Zhaoyang(Department of Cardiovascular Medicine,Changzhou Seventh People's Hospital(Changzhou Geriatrics Hospital Affiliated to Suzhou University),Changzhou,Jiangsu Province,213011 China)

机构地区：[1]常州市第七人民医院(苏州大学附属常州老年病医院)心血管内科,江苏常州213011

出　　处：《中外医疗》2022年第33期22-25,共4页China & Foreign Medical Treatment

摘　　要：目的分析利伐沙班抗凝治疗对改善高龄非瓣膜病房颤患者轻度认知功能障碍的有效性。方法随机选择常州市第七人民医院2019年1月-2021年12月收治的100例高龄非瓣膜病房颤患者为研究对象,依据随机抽签法分为对照组和观察组,各50例。对照组应用华法林治疗,观察组应用利伐沙班治疗,比较两组患者临床疗效、认知功能、凝血功能、不良事件。结果观察组临床总有效率为96.00%,高于对照组的82.00%,差异有统计学意义(χ^(2)=5.005,P<0.05)。观察组治疗后蒙特利尔认知评价量表(MoCA)、简易精神状态评价量表(MMSE)评分均高于对照组,差异有统计学意义(P<0.05)。观察组治疗后凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)均大于对照组,D-二聚体(D-D)、纤维蛋白原(FIB)数值均小于对照组,差异有统计学意义(P<0.05)。观察组不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论高龄非瓣膜病房颤患者应用利伐沙班治疗的效果更确切,不仅可以减轻患者认知功能障碍,还可以改善患者凝血功能,且不会明显增加不良事件的发生。Objective To analyze the effectiveness of rivaroxaban anticoagulation therapy on improving mild cognitive dysfunction in elderly patients with non-valvular atrial fibrillation.Methods 100 elderly patients with non-valvular ward fibrillation admitted to Changzhou Seventh People's Hospital from January 2019 to December 2021 were randomly selected as the research object,and divided them into control group and observation group according to random sampling method,with 50 patients in each group.The control group was treated with warfarin,and the observation group was treated with rivashaban.The clinical efficacy,cognitive function,coagulation function and adverse events were compared between the two groups.Results The total clinical effective rate of the observation group was 96.00%higher than that of the control group(82.00%),the difference was statistically significant(χ^(2)=5.005,P<0.05).After treatment,the scores of the Montreal Cognitive Assessment Scale(MoCA)and the Simple Mental State Assessment Scale(MMSE)in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).After treatment,the thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)and platelet count(PLT)in the observation group were higher than those in the control group,and the D-dimer(D-D)and fibrinogen(FIB)values were lower than those in the control group,the difference was statistically significant(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The effect of applying rivaroxaban therapy in elderly patients with non-valvular atrial fibrillation is more accurate,not only can reduce the cognitive dysfunction of patients,but also can improve the coagulation function of patients,and does not significantly increase the occurrence of adverse events.

关 键 词：非瓣膜病房颤 利伐沙班 临床疗效 认知功能 不良事件 

分 类 号：R541[医药卫生—心血管疾病]