不同甲泼尼龙琥珀酸钠给药方式在突发性耳聋患者中的应用效果研究  

Effect of Different Administration Modes of Methylprednisolone Sodium Succinate in Patients with Sudden Hearing Loss

作　　者：王力岩 郑志喜[1] 何志强[1] WANG Liyan;ZHENG Zhixi;HE Zhiqiang(Department of Otolaryngology,Fujian Clinical College of Medicine,Fujian Medical University/Fujian Provincial Hospital,Fuzhou,Fujian Province,350000 China)

机构地区：[1]福建医科大学福建省立临床医学院/福建省立医院耳鼻咽喉科,福建福州350000

出　　处：《中外医疗》2022年第36期94-98,共5页China & Foreign Medical Treatment

摘　　要：目的 探讨不同甲泼尼龙琥珀酸钠给药方式在突发性耳聋(sudden hearing loss,SHL)患者中的应用效果。方法 随机选取2020年2月—2021年12月福建省立金山医院收治的110例SHL患者为研究对象,采用随机数字表法分为对照组(55例)与研究组(55例)。对照组应用甲泼尼龙琥珀酸钠静脉滴注治疗,研究组应用甲泼尼龙琥珀酸钠耳后乳突骨膜下注射治疗。比较两组患者的临床疗效、治疗前后纯音听阈阈值、不良反应发生情况,以及随访6个月时复发率。结果 研究组总有效率(96.36%)较对照组(83.64%)高,差异有统计学意义(χ^(2)=4.950,P<0.05)。治疗前,两组纯音听阈阈值比较,差异无统计学意义(P>0.05);治疗后,研究组纯音听阈阈值较对照组低,差异有统计学意义(P<0.05)。研究组不良反应发生率(3.64%)较对照组(16.36%)低,差异有统计学意义(χ^(2)=4.950,P<0.05)。随访6个月,研究组复发率(1.82%)较对照组(14.55%)低,差异有统计学意义(χ^(2)=4.356,P<0.05)。结论 相较于静脉滴注全身给药方式,耳后乳突骨膜下注射甲泼尼龙琥珀酸钠治疗SHL的效果与安全性更为理想,能够有效改善患者的听力,抑制疾病复发。Objective To investigate the effects of different administration modes of methylprednisolone sodium succinate in patients with sudden hearing loss(SHL).Methods A total of 110 SHL patients admitted to Fujian Clinical College of Medicine from February 2020 to December 2021 were randomly selected as study subjects,and divided into control group(55 cases)and study group(55 cases)by random number table methed.The control group was treated with intravenous infusion of methylprednisolone sodium succinate,while the study group was treated with intravenous injection of methylprednisolone sodium succinate retroauricular mastoid process subperiosteal.The clinical efficacy,pure tone hearing threshold before and after treatment,occurrence of adverse reactions,and recurrence rate after 6 months of follow-up were compared between the two groups.Results The total effective rate(96.36%)in the study group was higher than 83.64%in the control group,the difference was statistically significant(χ^(2)=4.950,P<0.05).Before treatment,there was no statistically significant difference in pure tone hearing threshold between the two groups(P>0.05).After treatment,the pure tone hearing threshold of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).The comparison of adverse reactions in the study group(3.64%)was lower than(16.36%)of the control group,the difference was statistically significant(χ^(2)=4.950,P<0.05).The recurrence rate of the study group was 1.82%lower than 14.55%of the control group at 6 months,the difference was statistically significant(χ^(2)=4.356,P<0.05).Conclusion Compared with intravenous systemic administration,intravenous injection of methylprednisolone sodium succinate retroauricular mastoid process subperiosteal has better efficacy and safety in the treatment of SHL,which can effectively improve patients'hearing and inhibit disease recurrence,so it has clinical application and promotion value.

关 键 词：甲泼尼龙琥珀酸钠 给药方式 突发性耳聋 

分 类 号：R5[医药卫生—内科学]