姜黄石油醚部位的化学成分研究  

Study on the chemical constituents of the petroleum ether fraction of Curcuma longa L.

作　　者：都文文 宋成武 DU Wenwen;SONG Chengwu(The People's Hospital of Jiaozuo,Jiaozuo 454000,China;School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430074,China;College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]焦作市人民医院,焦作454000 [2]华中科技大学同济医学院药学院,武汉430074 [3]湖北中医药大学药学院,武汉430065

出　　处：《西北药学杂志》2023年第3期1-5,共5页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:31270392)。

摘　　要：目的 研究姜黄石油醚部位的化学成分。方法 用硅胶柱色谱、半制备高效液相色谱等现代分离技术以及重结晶等方法对姜黄石油醚部位的化学成分进行分离纯化,通过波谱技术并结合化合物的理化性质对分离得到的化合物进行结构鉴定。结果 从姜黄石油醚部位共分离得到10个化合物,分别鉴定为:姜黄烯(1),E-α-atlantone(2),芳姜黄酮(3),2-methyl-6-(4-methyl-5-one-3-cyclohexen)-2-hepten-4-one(4),2-methyl-6-(2-cyclohexen-4-one)-2-hepten-4-one(5),2-methyl-6-(4-methene-5-hydroxyl-2-cyclohexen)-2-hepten-4-one(6),bisacurone(7),姜黄烯醇(8),2-hydroxy-2-methyl-6-p-tolyl-4-heptanone(9),turmeronol A(10)。结论 化合物4首次从姜黄属植物中分离得到,化合物9为新的天然产物。Objective To study the chemical constituents of the petroleum ether fraction of Curcuma longa L.Methods The chemical constituents of the petroleum ether fraction of Curcuma longa L.were separated and purified by silica gel column chromatography,semi-preparative HPLC and recrystallization.The structures were elucidated by spectroscopic methods and previously reported data.Results 10 compounds were isolated and characterized as α-curcumene(1),E-α-atlantone(2),ar-turmerone(3),2-methyl-6-(4-methyl-5-one-3-cyclohexen)-2-hepten-4-one(4),2-methyl-6-(2-cyclohexen-4-one)-2-hepten-4-one(5),2-methyl-6-(4-methene-5-hydroxyl-2-cyclohexen)-2-hepten-4-one(6),bisacurone(7),curcumenol(8),2-hydroxy-2-methyl-6-p-tolyl-4-heptanone(9),and turmeronol A(10).Conclusion Compound 4 was isolated from this genus for the first time.Compound 9 was firstly isolated from this plant,which represents a new natural product.

关 键 词：姜黄属 姜黄 化学成分 分离鉴定 倍半萜 

分 类 号：R284[医药卫生—中药学]