荆花胃康胶丸联合益生菌治疗胃幽门螺杆菌阳性慢性胃炎及对胃幽门螺杆菌根除率的效果  

Curative effect of Jinghua Weikang Capsules combined with probiotics on Helicobacter pylori (Hp)-positive chronic gastritis and its influences on Hp eradication rate

作　　者：杨亚莉[1] 张志强[1] 魏毅强 赵丹 李少英 YANG Yali;ZHANG Zhiqiang;WEI Yiqiang;ZHAO Dan;LI Shaoying(The First Ward of the Department of Gastroenterology,Xinxiang First People's Hospital,Xinxiang 453099,China)

机构地区：[1]新乡市第一人民医院消化内科一病区,新乡453099

出　　处：《西北药学杂志》2023年第3期167-171,共5页Northwest Pharmaceutical Journal

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20200769)。

摘　　要：目的 探讨荆花胃康胶丸联合益生菌治疗胃幽门螺杆菌(Helicobacter pylori,Hp)阳性慢性胃炎的效果及对Hp根除率的影响。方法 选取130例Hp阳性慢性胃炎患者作为研究对象,按照随机数字表法分为2组,各65例。对照组患者接受常规四联疗法;观察组在常规疗法的基础上采用荆花胃康胶丸联合益生菌治疗。比较治疗有效率及Hp转阴率,并分析治疗前后临床症状积分、炎性因子[白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)和C-反应蛋白(C-reactive protein,CRP)]、胃肠激素[胃动素(motilin,MTL)、胃泌素(gastrin,GAS)及血管活性肠肽(vasoactive intestinal peptide,VIP)]及胃肠菌群变化情况,记录不良发应发生率。结果 治疗后,观察组有效率、Hp转阴率分别为96.67%、80.00%,均高于对照组(80.00%、53.33%),P<0.05;2组患者腹痛、腹胀、嗳气反酸和纳差等症状积分均较治疗前降低,且观察组各项积分显著低于对照组(P<0.05);2组IL-6、TNF-α、CRP和VIP水平降低,MTL、GAS水平升高,且观察组上述指标变化更显著(P<0.05);2组患者肠球菌、葡萄球菌数量增加,肠杆菌、乳杆菌、双歧杆菌数量减少,且观察组菌群数量变化幅度更小(P<0.05);治疗和随访期间,观察组皮疹、恶心等不良反应发生率比较差异无统计学意义(P>0.05)。结论 荆花胃康胶丸联合益生菌治疗Hp阳性慢性胃炎,可明显提升Hp转阴率,改善胃肠激素分泌功能及炎症,减轻对胃肠菌群平衡的破坏,安全性较好。Objective To explore the curative effect of Jinghua Weikang Capsules combined with probiotics on Helicobacter pylori(Hp)-positive chronic gastritis and its influences on Hp eradication rate.Methods A total of 130 patients with Hp-positive chronic gastritis were enrolled as the research objects.According to random number table method,they were divided into control group(routine quadruple therapy)and observation group(Jinghua Weikang Capsules combined with probiotics on the basis of control group),65 cases in each group.The response rate of treatment and negative conversion ratio of Hp were compared between the 2 groups.The changes in scores of clinical symptoms,the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),C-reactive protein(CRP),gastrointestinal hormones[motilin(MTL),gastrin(GAS),vasoactive intestinal peptide(VIP)]and gastrointestinal floras before and after treatment were analyzed.The incidence of adverse reactions was recorded.Results After treatment,the response rate of treatment and the negative conversion rate of Hp in observation group were 96.67%and 80.00%,higher than those in control group(80.00%,53.33%)(P<0.05).After treatment,the scores of clinical symptoms(abdominal pain,abdominal distension,belching and acid reflux,poor appetite)in both groups were decreased,which were significantly lower in observation group than in control group(P<0.05).After treatment,the levels of IL-6,TNF-α,CRP and VIP were decreased,while the levels of MTL and GAS were increased in both groups,and the changes of above indexes were more significant in observation group than in control group(P<0.05).After treatment,the number of Enterococcus and Staphylococcus was increased,while the levels of Enterobacter,Lactobacillus and Bifidobacterium were decreased in both groups,and the change amplitude of floras number was lower in observation group than in control group(P<0.05).During treatment and follow-up,there was no significant difference in the incidence of adverse reactions(rash,nausea)

关 键 词：荆花胃康胶丸 益生菌 常规四联疗法 慢性胃炎 幽门螺旋杆菌 肠道菌群 

分 类 号：R975[医药卫生—药品]