4种优势配伍方法治疗变应性鼻炎肺虚感寒证的回顾性研究  

Treatment of allergic rhinitis with syndrome of lung deficiency and cold attack by four superior drug matching:A retrospective study

作　　者：陆荣锦 薛珊珊 邱歆莹 王卓 吴拥军[2] LU Rongjin;XUE Shanshan;QIU Xinying;WANG Zhuo;WU Yongjun(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029 [2]南京中医药大学,江苏南京210023

出　　处：《现代中西医结合杂志》2023年第5期596-602,共7页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金面上项目(82174446);江苏省卫生健康科研课题(BJ18023);国家中医临床研究基地开放课题(JD201701)。

摘　　要：目的比较4种优势配伍方法治疗变应性鼻炎肺虚感寒证的有效性及特点。方法采用回顾性分析方法,选取2021年5月—2022年6月于南京中医药大学附属医院耳鼻喉科门诊就诊的120例变应性鼻炎肺虚感寒证患者的病例资料,根据用药的不同分为A组、B组、C组、D组,每组30例,分别采用布地奈德鼻喷剂联合辛夷散汤剂、布地奈德鼻喷剂联合鼻敏合剂1号、布地奈德鼻喷剂联合枸地氯雷他定片、布地奈德鼻喷剂联合氯雷他定片进行治疗,均连续用药14 d。比较4组治疗前后的鼻炎症状(TNSS)评分、鼻炎伴随症状(TNNSS)评分、鼻腔体征评分、鼻结膜炎生活质量调查问卷(RQLQ)评分、中医证候积分及临床疗效、用药期间出现的不良反应。结果治疗后,4组各项评分均较治疗前明显降低(P均<0.05);4组治疗后TNNSS总分及鼻腔体征评分比较差异均无统计学意义(P均>0.05);A组治疗后TNSS总分及中医证候积分均明显低于D组(P均<0.05),RQLQ总分明显低于C组、D组(P均<0.05)。A组总有效率为93.3%(28/30),B组为90.0%(27/30),C组为83.3%(25/30),D组为76.7%(23/30),4组总有效率比较差异无统计学意义(P均>0.05)。A组愈显率为73.3%(22/30),B组为56.7%(17/30),C组为46.7%(14/30),D组为36.7%(11/30),A组愈显率明显高于C组、D组(P均<0.05),但与B组比较差异无统计学意义(P>0.05)。4组患者治疗期间均未见明显不良反应。结论临床常用的4种优势配伍方法治疗变应性鼻炎肺虚感寒证均有良好的临床疗效,但中药汤剂联合常规西药在改善鼻部症状及全身症状方面效果更佳,整体疗效优于其他治疗方案,中西药联合治疗可能有增效作用,有利于提高临床有效率。Objective It is to compare the effectiveness and characteristics of four superior drug matching in the treatment of allergic rhinitis with syndrome of lung deficiency and cold attack.Methods The case data of 120 patients with allergic rhinitis with syndrome of lung deficiency and cold attack treated in the outpatient clinic of the Department of Otorhinolaryngology of the Affiliated Hospital of Nanjing University of Chinese Medicine from May 2021 to June 2022 were selected through a retrospective analysis,and the patients were divided into group A,group B,group C and group D according to their medications,with 30 cases in each group,and were respectively treated with budesonide nasal spray combined with xingyisan decoction,budesonide nasal spray combined with Bimin mixture I,budesonide nasal spray combined with desloratadine citrate disodium tablets,and budesonide nasal spray combined with loratadine tablets,all of which were administered continuously for 14 days.The total nasal symptoms scale(TNSS)scores,total non-nasal symptom scale(TNNSS)scores,nasal signs scores,rhinoconjunctivitis quality of life questionnaire(RQLQ)scores,traditional Chinese medicine symptom scores before and after treatment and the clinical efficacy and adverse reactions occurred during the drug administration of the four groups were compared.Results After treatment,the scores of all four groups were significantly lower than those before treatment(all P<0.05),the differences in the total TNNSS scores and nasal signs scores were not statistically significant among the four groups(all P>0.05),the total TNSS scores and traditional Chinese medicine symptom scores in group A were significantly lower than those in group D(all P<0.05),and the total RQLQ scores were significantly lower than those in groups C and group D(all P<0.05).The total effective rate was 93.3%(28/30)in group A,90.0%(27/30)in group B,83.3%(25/30)in group C,and 76.7%(23/30)in group D,and the difference in total effective rate among the four groups was not statistically significa

关 键 词：变应性鼻炎 肺虚感寒证 辛夷散 布地奈德鼻喷剂 枸地氯雷他定 氯雷他定 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]