五水头孢唑林钠治疗扁桃体周围炎的临床疗效及对PCT、TNF-α及IL-6水平的影响  

Clinical Efficacy of Cefazolin Sodium Pentahydrate in the Treatment of Peritonsillitis and its Effect on PCT,TNF-αand IL-6 Levels

作　　者：秦燕 QIN Yan(Department of Otolaryngological,Nantong Tongzhou District Hospital of Traditional Chinese Medicine,Nantong 226300,Jiangsu,China)

机构地区：[1]南通市通州区中医院耳鼻喉科,江苏南通226300

出　　处：《医学信息》2023年第9期106-108,123,共4页Journal of Medical Information

摘　　要：目的研究五水头孢唑林钠治疗扁桃体周围炎的临床疗效及对PCT、TNF-α及IL-6水平的影响。方法选取2019年1月-2021年9月我院诊治的164例扁桃体周围炎患者为研究对象,采用随机数字表法分为观察组和对照组,各82例。对照组采用头孢唑林钠治疗,观察组采用五水头孢唑林钠治疗,比较两组临床疗效、炎症因子水平[降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、临床症状消失时间、不良反应发生率及治疗费用。结果观察组治疗总有效率为95.12%,与对照组的93.90%比较,差异无统计学意义(P>0.05);两组治疗后PCT、TNF-α、IL-6水平均低于治疗前,且观察组低于对照组(P<0.05);观察组退热、咽痛、扁桃体肿大消失时间均短于对照组(P<0.05);观察组不良反应发生率为3.66%,低于对照组的12.20%(P<0.05);观察组治疗费用高于对照组(P<0.05)。结论五水头孢唑林钠治疗扁桃体周围炎的临床疗效满意,可缩短临床症状消失时间,改善炎症因子水平,降低不良反应发生率,但治疗成本较高,临床应结合患者具体情况科学合理选择。Objective To study the clinical efficacy of cefazolin sodium pentahydrate in the treatment of peritonsillitis and its effect on PCT,TNF-αand IL-6 levels.Methods A total of 164 patients with peritonsillitis diagnosed and treated in our hospital from January 2019 to September 2021 were selected as the research objects.They were divided into observation group and control group by random number table method,with 82 cases in each group.The control group was treated with cefazolin sodium,and the observation group was treated with cefazolin sodium pentahydrate.The clinical efficacy,levels of inflammatory factors[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],disappearance time of clinical symptoms,incidence of adverse reactions and treatment costs were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.12%,which was compared with 93.90%in the control group,the difference was not statistically significant(P>0.05).After treatment,the levels of PCT,TNF-αand IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The disappearance time of fever,sore throat and tonsil enlargement in the observation group was shorter than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 3.66%,which was lower than 12.20%in the control group(P<0.05).The treatment cost of the observation group was higher than that of the control group(P<0.05).Conclusion The clinical efficacy of cefazolin sodium pentahydrate in the treatment of peritonsillitis is satisfactory,which can shorten the disappearance time of clinical symptoms,improve the level of inflammatory factors and reduce the incidence of adverse reactions.However,the cost of treatment is high.Clinically,it should be scientifically and reasonably selected according to the specific conditions of patients.

关 键 词：五水头孢唑林钠 头孢唑林钠 扁桃体周围炎 炎症因子 

分 类 号：R766.18[医药卫生—耳鼻咽喉科]