男性尖锐湿疣患者血清IL-12、IL-10水平及其对复发的预测价值  

Serum Levels of IL-12 and IL-10 and Their Predictive Value for Recurrence in Male Patients with Condyloma Acuminatum

作　　者：郝伟丽[1] 常海燕[2] 张恒坡[1] 曹冰青[1] HAO Weili;CHANG Haiyan;ZHANG Hengpo;CAO Bingqing(Department of Dermatology,Anyang District Hospital,Anyang 455000,China;Outpatient Department,Anyang District Hospital,Anyang 455000,China)

机构地区：[1]安阳地区医院皮肤科,河南安阳455000 [2]安阳地区医院门诊部,河南安阳455000

出　　处：《河南医学研究》2023年第7期1274-1278,共5页Henan Medical Research

摘　　要：目的探讨血清白细胞介素(IL)-12、IL-10在男性尖锐湿疣(CA)患者CO_(2)激光联合5-氨基酮戊酸光动力(ALA-PDT)治疗前后的变化及对复发的预测价值。方法选取2020年1月至2021年6月于安阳地区医院接受治疗并随访至2022年1月的112例CA患者作为研究对象,均接受CO_(2)激光联合ALA-PDT治疗,对比治疗前后的血清IL-12、IL-10水平,并根据患者治疗后是否复发分为复发组(n=23)与未复发组(n=89),分析一般资料与血清IL-12、IL-10的相关性;采用受试者工作特征(ROC)曲线分析IL-12、IL-10预测复发的效能。结果112例CA患者治愈率为90.18%,不良反应发生率为1.79%,复发率为20.54%,且治疗后血清IL-12高于治疗前,IL-10低于治疗前(P<0.05)。复发组与未复发组在年龄、婚姻情况、吸烟史、饮酒史、受教育程度、正常使用安全套等方面差异无统计学意义(P>0.05),而在皮损数量、皮损部位、人乳头状瘤病毒(HPV)感染情况、治疗前IL-12、IL-10方面差异有统计学意义(P<0.05)。logistic回归分析显示,多个皮损部位、多重HPV感染、皮损数量增加及治疗前血清IL-12下降、IL-10升高是影响CA患者复发的独立危险因素(P<0.05)。Pearson相关性分析显示,皮损数量与IL-10呈正相关(P<0.05);Spearman相关性分析显示,HPV感染情况、皮损部位与IL-12呈负相关,与IL-10呈正相关(P<0.05)。ROC曲线分析显示,IL-12、IL-10预测CA复发的曲线下面积(AUC)分别为0.920、0.709,敏感度分别为95.70%、91.30%,特异度分别为89.90%、50.60%。结论血清IL-12、IL-10在CA患者中呈异常表达,CO_(2)激光联合ALA-PDT治疗有利于降低IL-10和提高IL-12水平,并且动态监测IL-12、IL-10有利于为预测CA复发提供重要参考。Objective To investigate the changes of serum interleukin(IL)-12 and IL-10 in male condyloma acuminatum(CA)patients before and after treatment with CO_(2) laser combined with 5-aminolevulinic acid-based photodynamic therapy(ALA-PDT)and their predictive value for recurrence.Methods A total of 112 CA patients who received treatment in Anyang District Hospital from January 2020 to June 2021 and were followed up until January 2022 were selected as the research subjects,all received CO_(2) laser combined with ALA-PDT treatment.The serum IL-12,IL-10 expression before and after treatment were compared.Patients were divided into relapse group(n=23)and non-relapse group(n=89)according to whether the patients relapsed after treatment,and the correlation between general data and serum IL-12 and IL-10 was analyzed.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of IL-12 and IL-10 in predicting relapse.Results The cure rate of 112 patients with CA was 90.18%,the incidence of adverse reactions was 1.79%,and the recurrence rate was 20.54%,and the serum IL-12 after treatment was higher than before treatment,and IL-10 was lower than before treatment(P<0.05).There was no statistically significant difference in age,marriage status,smoking history,drinking history,education level and normal condom use between the relapse group and the non-relapse group(P>0.05),but there was statistically significant difference in the number of skin lesions,skin lesions,human papillomavirus(HPV)infection,IL-12 and IL-10 before treatment(P<0.05).Logistic regression analysis showed that multiple lesions,multiple HPV infection,increased number of lesions,decreased serum IL-12 and increased serum IL-10 before treatment were independent risk factors for recurrence in CA patients(P<0.05).Pearson correlation analysis showed that the number of skin lesions was positively correlated with IL-10(P<0.05).Spearman correlation analysis showed that HPV infection and lesion site were negatively correlated with IL-12,but positively correl

关 键 词：尖锐湿疣 白细胞介素-12 白细胞介素-10 复发 预测 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]