Effects of pore interconnectivity on bone regeneration in carbonate apatite blocks  

作　　者：Maab Elsheikh Ryo Kishida Koichiro Hayashi Akira Tsuchiya Masaya Shimabukuro and Kunio Ishikawa 

机构地区：[1]Department of Biomaterials,Faculty of Dental Science,Kyushu University,3-1-1 Maidashi Higashi-ku,Fukuoka 812-8582,Japan

出　　处：《Regenerative Biomaterials》2022年第1期30-40,共11页再生生物材料（英文版）

摘　　要：Porous architecture in bone substitutes,notably the interconnectivity of pores,is a critical factor for bone ingrowth.However,controlling the pore interconnectivity while maintaining the microarchitecture has not yet been achieved using conventional methods,such as sintering.Herein,we fabricated a porous block using the crystal growth of calcium sulfate dihydrate,and controlled the pore interconnectivity by limiting the region of crystal growth.The calcium sulfate dihydrate blocks were transformed to bone apatite,carbonate apatite(CO_(3)Ap)through dissolution–precipitation reactions.Thus,CO_(3)Ap blocks with 15%and 30%interconnected pore volumes were obtained while maintaining the microarchitecture:they were designated as CO_(3)Ap-15 and CO_(3)Ap-30,respectively.At 4 weeks after implantation in a rabbit femur defect,new bone formed throughout CO_(3)Ap-30,whereas little bone was formed in the center region of CO_(3)Ap-15.At 12 weeks after implantation,a large portion of CO_(3)Ap-30 was replaced with new bone and the boundary with the host bone became blurred.In contrast,CO_(3)Ap-15 remained in the defect and the boundary with the host bone was still clear.Thus,the interconnected pores promote bone ingrowth,followed by replacement of the material with new bone.These findings provide a useful guide for designing bone substitutes for rapid bone regeneration.

关 键 词：bone substitutes carbonate apatite pore interconnectivity bone regeneration 

分 类 号：O61[理学—无机化学]