Bioinspired laminated bioceramics with high toughness for bone tissue engineering  

作　　者：Jinzhou Huang Dong Zhai Jianmin Xue Tian Li Dudi Ren Chengtie Wu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,P.R.China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,P.R.China

出　　处：《Regenerative Biomaterials》2022年第1期739-749,共11页再生生物材料（英文版）

基　　金：supported by the National key Research and Development Program of China(2021YFA0715700);the Natural Science Foundation of China(32130062);Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-003).

摘　　要：For the research of biomaterials in bone tissue engineering,it is still a challenge to fabricate bioceramics that overcome brittleness whilemaintaining the great biological performance.Here,inspired by the toughness of naturalmaterials with hierarchical laminated structure,we presented a directional assembly-sintering approach to fabricate laminated MXene/calcium silicate-based(L-M/CS)bioceramics.Benefiting from the orderly laminated structure,the LM/CS bioceramics exhibited significantly enhanced toughness(2.23MPa·m^(1/2))and high flexural strength(145MPa),which were close to the mechanical properties of cortical bone.Furthermore,the L-M/CS bioceramics possessed more suitable degradability than traditional CaSiO_(3)bioceramics due to the newly formed CaTiSiO_(5)after sintering.Moreover,the L-M/CS bioceramics showed good biocompatibility and could stimulate the expression of osteogenesisrelated genes.The mechanism of promoting osteogenic differentiation had been shown to be related to theWnt signaling pathway.This work not only fabricated calciumsilicate-based bioceramics with excellentmechanical and biological properties for bone tissue engineering but also provided a strategy for the combination of bionics and bioceramics.

关 键 词：laminated bioceramics MXene bioinspired structure high toughness bone tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]