Evaluation of the performance of Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating on biodegradable high-purity magnesium in a femoral condyle defect model in rabbits  

作　　者：Shibo Huang Junlei Li Kairong Qin Zhiqiang Wang Jiahui Yang Fang Cao Weirong Li Yupeng Liu Lipeng Liu Dewei Zhao 

机构地区：[1]Faculty of Electronic Information and Electrical Engineering,School of Biomedical Engineering,Dalian University of Technology,No.2 Linggong Road,Ganjingzi District,Dalian,Liaoning 116024,China [2]Orthopaedic Department Affiliated Zhongshan Hospital of Dalian University,No.6 Jiefang Street,Zhongshan District,Dalian,Liaoning 116001,China [3]Department of Optoelectronic Engineering and Instrumentation Science,Dalian University of Technology,No.2 Linggong Road,Ganjingzi District,Dalian,Liaoning 116024,China [4]Dongguan Eontec Co.,Ltd,Songshan Lake Science and Technology Industrial Park,Dongguan,Guangdong 523000,China

出　　处：《Regenerative Biomaterials》2022年第1期806-815,共10页再生生物材料（英文版）

基　　金：supported by Dalian Health Commission,medical key specialty of Dengfeng project[grant number(2021)243];National Orthopedics and Sports Rehabilitation Clinical Research Center Innovation Fund(2021-NCRC-CXJJ-ZH-28).

摘　　要：The two most critical factors in promoting the clinical translation of magnesium(Mg)are reducing its degradation rate and improving its osteogenesis.In this study,a Ca-deficient hydroxyapatite(CDHA)/MgF_(2)bilayer coating was prepared on high-purity magnesium(HP Mg)rods by fluorination and hydrothermal treatment.Scanning electron microscope showed that the thickness of the bilayer coating was 3.78 lm and that the surface morphology was nanoscale.In an in vivo experiment on femoral condyle defects in rabbits,the serum magnesium ion levels of rabbits were always in the normal range after surgery,and the liver and kidney functions were not abnormal,which indicated that the CDHA/MgF_(2)bilayer coating has good biosafety.Micro-CT showed that the CDHA/MgF_(2)bilayer coating significantly reduced the degradation rate of the HP Mg rods and enhanced the promotion of bone formation.Hard tissue sections showed that the CDHA/MgF_(2)bilayer coating gave the bone tissue a tight contact interface with the HP Mg rod and improved the bone mass.Immunohistochemistry showed that the expression of vascular endothelial growth factor and BMP-2 was more obvious.These results confirm that the CDHA/MgF_(2)bilayer coating can improve the properties of HP Mg and provide a basis for the further transformation of HP Mg in the future.It also provides a new reference for the surface modification of magnesiummetal.

关 键 词：high-purity magnesium MgF_(2) Ca-deficient hydroxyapatite femoral condyle 

分 类 号：R318.08[医药卫生—生物医学工程]