Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and antiinflammatory capacity for facilitating pelvic floor repair  

作　　者：Chenghao Wu Zixuan Zhou Xi You Yi Guo Ping Chen Huaifang Li Xiaowen Tong 

机构地区：[1]Department of Obstetrics and Gynecology,Tongji Hospital,Tongji University School of Medicine,Shanghai 200065,People’s Republic of China [2]Department of Burn Surgery,The First Affiliated Hospital of Naval Medical University,Burn Institute of PLA,Shanghai 200433,People’s Republic of China [3]School of Life Sciences and Technology,Tongji University,Shanghai 200092,People’s Republic of China

出　　处：《Regenerative Biomaterials》2022年第1期871-887,共17页再生生物材料（英文版）

基　　金：supported by the National Natural Science Foundation of China(82071630,81771560,81802583,81702745);Tongji Hospital National Natural Science Foundation Training Project(GJPY2119).

摘　　要：The application of polypropylene mesh(PPM)in pelvic organ prolapse(POP)treatment was severely limited by the complications associated with PPM,such as mesh exposure,chronic inflammatory reactions and postoperative hematoma.This study applied a method of fabricating a hydrogel-mesh complex(PPM+TA@GelMA)to cross-link tannic acid(TA)directly with Methacrylate Gelatin(GelMA)hydrogel and thus to form a coating for PPM.This one-step coating modification improved the hydrophilicity and cyto-compatibility of PPM.The hemostatic effect of PPMtTA@GelMA was confirmed through tail amputation test.Through the defect tissue repair experiments in vivo,it was proved that PPMtTA@GelMA had effects of anti-inflammation and promoting tissue repair and regulated the M2 subtype macrophages polarization for tissue repair.The TAloaded hydrogel coating endued PPM with multiple functions.It is believed that the novel hydrogel-mesh complex and its fabrication method will have great significance in basic research and clinical application.

关 键 词：tannic acid HYDROGEL polypropylene mesh pelvic floor repair 

分 类 号：TQ427.26[化学工程]