Additively manufactured pure zinc porous scaffolds for critical-sized bone defects of rabbit femur  

作　　者：Dandan Xia Yu Qin Hui Guo Peng Wen Hong Lin Maximilian Voshage Johannes Henrich Schleifenbaum Yan Cheng Yufeng Zheng 

机构地区：[1]Department of Dental Materials,Peking University School and Hospital of Stomatology,Beijing,100081,China [2]National Center of Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing Key Laboratory of Digital Stomatology,Research Center of Engineering and Technology for Digital Dentistry Ministry of Health,NMPA Key Laboratory for Dental Materials,Beijing,100081,China [3]The State Key Laboratory of Tribology,Tsinghua University,Beijing,100084,China [4]Department of Mechanical Engineering,Tsinghua University,Beijing,100084,China [5]School of Materials Science and Engineering,Peking University,Beijing,100871,China [6]Digital Additive Production(DAP),RWTH Aachen University,52074,Aachen,Germany [7]Biomed-X Center,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,100871,China

出　　处：《Bioactive Materials》2023年第1期12-23,共12页生物活性材料（英文）

基　　金：supported by the National Key R&D Program of China[grant number 2018YFE0104200];the National Natural Science Foundation of China[grant numbers 51901003,51931001,52171233,51875310];the Beijing Natural Science Foundation[grant number L212014];the Open Project of NMPA Key Laboratory for Dental Materials[grant number PKUSS20200401].

摘　　要：Additive manufacturing has received attention for the fabrication of medical implants that have customized and complicated structures.Biodegradable Zn metals are revolutionary materials for orthopedic implants.In this study,pure Zn porous scaffolds with diamond structures were fabricated using customized laser powder bed fusion(L-PBF)technology.First,the mechanical properties,corrosion behavior,and biocompatibility of the pure Zn porous scaffolds were characterized in vitro.The scaffolds were then implanted into the rabbit femur critical-size bone defect model for 24 weeks.The results showed that the pure Zn porous scaffolds had compressive strength and rigidity comparable to those of cancellous bone,as well as relatively suitable degradation rates for bone regeneration.A benign host response was observed using hematoxylin and eosin(HE)staining of the heart,liver,spleen,lungs,and kidneys.Moreover,the pure Zn porous scaffold showed good biocompatibility and osteogenic promotion ability in vivo.This study showed that pure Zn porous scaffolds with customized structures fabricated using L-PBF represent a promising biodegradable solution for treating large bone defects.

关 键 词：Additive manufacturing Laser powder bed fusion Scaffolds Pure Zn Critical-sized bone defect 

分 类 号：R318.08[医药卫生—生物医学工程]