A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration  

作　　者：Lingbin Che Ying Wang Dongyong Sha Guangyi Li Ziheng Wei Changsheng Liu Yuan Yuan Dianwen Song 

机构地区：[1]Department of Orthopedics,Shanghai General Hospital,Shanghai Jiaotong University School of Medicine,Shanghai,200080,PR China [2]Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry and School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,PR China [3]Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai,201210,PR China

出　　处：《Bioactive Materials》2023年第1期75-87,共13页生物活性材料（英文）

基　　金：supported by National Natural Science Foundation of China for Innovative Research Groups(No.51621002);Frontiers Science Center for Materiobiology and Dynamic Chemistry(No.JKVD1211002);National Natural Science Foundation of China(Nos.81571828,31771040,31971264).

摘　　要：Osteoporosis is one of the most disabling consequences of aging,osteoporotic fractures and higher risk of the subsequent fractures leading to substantial disability and deaths,indicating both local fractures healing and the early anti-osteoporosis therapy are of great significance.Teriparatide is strong bone formation promoter effective in treating osteoporosis,while side effects limit clinical applications.Traditional drug delivery is lack of sensitive and short-term release,finding a new non-invasive and easily controllable drug delivery to not only repair the local fractures but also improve total bone mass has remained a great challenge.Thus,bioinspired by the natural bone components,we develop appropriate interactions between inorganic biological scaffolds and organic drug molecules,achieving both loaded with the teriparatide in the scaffold and capable of releasing on demand.Herein,biomimetic bone microstructure of mesoporous bioglass,a near-infrared ray triggered switch,thermosensitive liposomes based on a valve,and polydopamine coated as a heater is developed rationally for osteoporotic bone regeneration.Teriparatide is pulsatile released from intelligent delivery,not only rejuvenating osteoporotic bone defect,but also presenting strong systemic anti-osteoporosis therapy.This biomimetic bone carrying novel drug delivery platform is well worth expecting to be a new promising strategy and clinically commercialized to help patients survive from the osteoporotic fracture.

关 键 词：Precise pulsatile release TERIPARATIDE Smart delivery Osteoporotic bone regeneration 

分 类 号：R681[医药卫生—骨科学]