Bone without borders-Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope  

作　　者：Furqan A.Shah Martina Jolic Chiara Micheletti Omar Omar Birgitta Norlindh Lena Emanuelsson Håkan Engqvist Thomas Engstrand Anders Palmquist Peter Thomsen 

机构地区：[1]Department of Biomaterials,Sahlgrenska Academy,University of Gothenburg,Gothenburg,Sweden [2]Department of Materials Science and Engineering,McMaster University,Hamilton,Ontario,Canada [3]Department of Engineering Sciences,Applied Materials Science Section,Uppsala University,Uppsala,Sweden [4]Department of Reconstructive Plastic Surgery,Karolinska University Hospital,Stockholm,Sweden

出　　处：《Bioactive Materials》2023年第1期103-114,共12页生物活性材料（英文）

摘　　要：Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive biomaterials.As proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium pyrophosphate)guides osteogenesis beyond the physiological envelope.In a sheep model,hollow dome-shaped constructs were placed directly over the occipital bone.At 12 months,large amounts of bone(~75%)occupy the hollow space with strong evidence of ongoing remodelling.Features of both compact bone(osteonal/osteon-like arrangements)and spongy bone(trabeculae separated by marrow cavities)reveal insights into function/need-driven microstructural adaptation.Pores within the CaP also contain both woven bone and vascularised lamellar bone.Osteoclasts actively contribute to CaP degradation/removal.Of the constituent phases,only calcium pyrophosphate persists within osseous(cutting cones)and non-osseous(macrophages)sites.From a translational perspective,this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge.

关 键 词：BONE Calcium phosphate Monetite Calcium pyrophosphate Electron microscopy Raman spectroscopy 

分 类 号：R318.08[医药卫生—生物医学工程]