Natural,synthetic and commercially-available biopolymers used to regenerate tendons and ligaments  

作　　者：Behzad Shiroud Heidari Rui Ruan Ebrahim Vahabli Peilin Chen Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle 

机构地区：[1]Vascular Engineering Laboratory,Harry Perkins Institute of Medical Research,QEII Medical Centre and the UWA Centre for Medical Research,The University of Western Australia,Nedlands,6009,Australia [2]School of Engineering,The University of Western Australia,Perth,Australia [3]Australian Research Council Centre for Personalised Therapeutics Technologies,Australia [4]Division of Surgery(Orthopaedics),Medical School,The University of Western Australia,Perth,Australia [5]T3mPLATE,Harry Perkins Institute of Medical Research,QEII Medical Centre and the UWA Centre for Medical Research,The University of Western Australia,Nedlands,6009,Australia [6]Science and Engineering Faculty,Queensland University of Technology,Brisbane,Queensland,Australia [7]Perron Institute for Neurological and Translational Science,Nedlands,6009,Australia [8]BHF Centre for Cardiovascular Science,The University of Edinburgh,UK

出　　处：《Bioactive Materials》2023年第1期179-197,共19页生物活性材料（英文）

基　　金：supported by the Department of Jobs,Tourism,Science and Innovation(JTSI),Government of Western Australia,through the Science Industry PhD Fellowship Program.

摘　　要：Tendon and ligament(TL)injuries affect millions of people annually.Biopolymers play a significant role in TL tissue repair,whether the treatment relies on tissue engineering strategies or using artificial tendon grafts.The biopolymer governs the mechanical properties,biocompatibility,degradation,and fabrication method of the TL scaffold.Many natural,synthetic and hybrid biopolymers have been studied in TL regeneration,often combined with therapeutic agents and minerals to engineer novel scaffold systems.However,most of the advanced biopolymers have not advanced to clinical use yet.Here,we aim to review recent biopolymers and discuss their features for TL tissue engineering.After introducing the properties of the native tissue,we discuss different types of natural,synthetic and hybrid biopolymers used in TL tissue engineering.Then,we review biopolymers used in commercial absorbable and non-absorbable TL grafts.Finally,we explain the challenges and future directions for the development of novel biopolymers in TL regenerative treatment.

关 键 词：Synthetic biopolymers Natural biopolymers Hybrid composites Tendon scaffolds Commercial grafts 

分 类 号：R318.08[医药卫生—生物医学工程]