Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications  

作　　者：Fan Rong Tengjiao Wang Qian Zhou Haowei Peng Jingtian Yang Quli Fan Peng Li 

机构地区：[1]Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME),Northwestern Polytechnical University(NPU),127 West Youyi Road,Xi’an,Shaanxi,710072,PR China [2]National Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications,Nanjing,210023,PR China [3]Honors College,Northwestern Polytechnical University(NPU),127 West Youyi Road,Xi’an,Shaanxi,710072,PR China [4]Queen Mary University of London Engineering School,Northwestern Polytechnical University(NPU),127 West Youyi Road,Xi’an,Shaanxi,710072,PR China

出　　处：《Bioactive Materials》2023年第1期198-216,共19页生物活性材料（英文）

基　　金：supports from National Natural Science Foundation of China(52003224,52073230);Natural Science Basic Research Program of Shaanxi Province(2020GXLH-Z-013,2019JQ-157);Natural Science Foundation of Ningbo(202003N4051).

摘　　要：Hydrogen sulfide(H_(2)S)plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries,promoting tissue regeneration,and regulating the process of various diseases caused by physiological disorders.Studies have revealed that the physiological effects of H_(2)S are highly associated with its concentrations.At relatively low concentration,H_(2)S shows beneficial functions.However,long-time and high-dose donation of H_(2)S would inhibit regular biological process,resulting in cell dysfunction and apoptosis.To regulate the dosage of H_(2)S delivery for precision medicine,H_(2)S delivery systems with intelligent characteristics were developed and a variety of biocompatibility polymers have been utilized to establish intelligent polymeric H_(2)S delivery systems,with the abilities to specifically target the lesions,smartly respond to pathological microenvironments,as well as real-timely monitor H_(2)S delivery and lesion conditions by incorporating imaging-capable moieties.In this review,we focus on the design,preparation,and therapeutic applications of intelligent polymeric H_(2)S delivery systems in cardiovascular therapy,inflammatory therapy,tissue regenerative therapy,cancer therapy and bacteria-associated therapy.Strategies for precise H_(2)S therapies especially imaging-guided H_(2)S theranostics are highlighted.Since H_(2)S donors with stimuli-responsive characters are vital components for establishing intelligent H_(2)S delivery systems,the development of H_(2)S donors is also briefly introduced.

关 键 词：Hydrogen sulfide prodrug Smart drug delivery Gas therapy Reactive sulfur species Precision medicine 

分 类 号：R318.08[医药卫生—生物医学工程]