Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury  

作　　者：Hao Wei Dawei Jiang Bo Yu Dalong Ni Mengting Li Yin Long Paul A.Ellison Cerise M.Siamof Liang Cheng Todd E.Barnhart Hyung-Jun Im Faquan Yu Xiaoli Lan Xiaohua Zhu Qianjun He Weibo Cai 

机构地区：[1]Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]National-Regional Key Technology Engineering Laboratory for Medical Ultrasound,Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Shenzhen University,Shenzhen,518060,China [3]Departments of Radiology and Medical Physics,University of Wisconsin–Madison,Madison,WI,53705,USA [4]Department of Nuclear Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Ave,Wuhan,430030,China [5]Key Laboratory for Green Chemical Process of Ministry of Education,School of Chemical Engineering and Pharmacy,Wuhan Institute of Technology,Wuhan,430073,China [6]Institute of Functional Nano&Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University,Suzhou,215123,China [7]University of Wisconsin Carbone Cancer Center,University of Wisconsin–Madison,Madison,WI,53705,USA

出　　处：《Bioactive Materials》2023年第1期282-291,共10页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(81601605,21571147,82102121);the Postdoctoral Science Foundation of China(2016M600670);supported by the University of Wisconsin–Madison,the National Institutes of Health(NIBIB/NCI P30CA014520);the Natural Science Foundation of SZU(Grant No.827-000143);the Shenzhen Peacock Plan(KQTD2016053112051497).

摘　　要：Acute kidney injury(AKI)leads to unacceptably high mortality due to difficulties in timely intervention and less efficient renal delivery of therapeutic drugs.Here,a series of polyvinylpyrrolidone(PVP)-curcumin nanoparticles(PCurNP)are designed to meet the renal excretion threshold(~45 kDa),presenting a controllable delivery nanosystem for kidney targeting.Renal accumulation of the relatively small nanoparticles,^(89)Zr-PCurNP M10 with the diameter between 5 and 8 nm,is found to be 1.7 times and 1.8 times higher than the accumulation of^(89)Zr-PCurNP M29(20-50 nm)and M40(20-50 nm)as revealed by PET imaging.Furthermore,serum creatinine analysis,kidney tissues histology,and tubular injury scores revealed that PCurNP M10 efficiently treated cisplatin-induced AKI.Herein,PCurNP offers a novel and simple strategy for precise PET image-guided drug delivery of renal protective materials.

关 键 词：NANOMEDICINE Acute kidney injury Kidney targeting Positron emission tomography(PET)imaging Zirconium-89(^(89)Zr) Nuclear medicine 

分 类 号：R692[医药卫生—泌尿科学]