健肝乐颗粒治疗新生儿病理性黄疸湿热内蕴证的临床研究  

Clinical effect of Jianganle granules for neonatal pathological jaundice of internal retention of damp-heat syndrome

作　　者：蔡在胜 蔡保欢 CAI Zaisheng;CAI Baohuan(Department of Pediatrics,Tongji Hospital,Tongji Medical College of HUST,Wuhan,Hubei 430000)

机构地区：[1]华中科技大学同济医学院附属同济医院儿科,湖北武汉430000

出　　处：《河北中医》2023年第4期593-596,共4页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察健肝乐颗粒治疗新生儿病理性黄疸湿热内蕴证的临床效果。方法将199例病理性黄疸湿热内蕴证患儿按照简单随机抽样法分为2组,对照组104例予常规蓝光治疗,治疗组95例在对照组基础上加用健肝乐颗粒治疗。2组均治疗3~5天后统计疗效,比较2组治疗前后新生儿神经行为测定(NBNA)评分、经皮胆红素(TCB)及血清总胆红素(TBiL)、总胆汁酸(TBA)、白细胞介素6(IL-6)、降钙素原(PCT)、胱抑素C(CysC)水平变化情况,比较2组治疗期间不良反应发生情况。结果治疗组总有效率97.89%(93/95),不良反应总发生率2.11%(2/95),对照组总有效率82.69%(86/104),不良反应总发生率10.58%(11/104),治疗组总有效率高于对照组(P<0.05),不良反应总发生率低于对照组(P<0.05)。与本组治疗前比较,2组治疗后NBNA评分均升高(P<0.05),且治疗组治疗后NBNA评分高于对照组(P<0.05)。与本组治疗前比较,2组治疗后TCB水平均降低(P<0.05),且治疗组治疗后TCB水平低于对照组(P<0.05)。与本组治疗前比较,2组治疗后TBiL、TBA、IL-6、PCT及CysC水平均降低(P<0.05),且治疗组治疗后TBiL、TBA、IL-6、PCT及CysC水平均低于对照组(P<0.05)。结论健肝乐颗粒治疗新生儿病理性黄疸湿热内蕴证疗效确切,可有效降低患儿胆红素水平,保护患儿神经系统发育,抑制炎性反应,预防并发症的发生,减少不良反应的发生。Objective To observe the clinical effect of Jianganle granules for neonatal pathological jaundice(internal retention of damp-heat syndrome).Methods One hundred ninety-nine cases with neonatal pathological jaundice(internal retention of damp-heat syndrome)were assigned into the treatment group(n=95)and the control group(n=104)by simple random sampling.All patients were managed by conventional blue light,and those in the treatment group were additionally treated with Jianganle granules.Treated for 3-5 days,the aim was to compare Neonatal Behavioral Neurological Assessment(NBNA)scores,transcutaneous bilirubin(TCB),serum total bilirubin(TBIL),total bile acid(TBA),interleukin-6(IL-6),procalcitonin(PCT),cystatin C(CysC).The curative effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(97.89%[93/95]vs 82.69%[86/104],[P<0.05],respectively).The total incidence of adverse reactions was 2.11%(2/95)in the treatment group,lower than that of 10.58%(11/104)in the control group(P<0.05).After treatment,NBNA scores in groups were increased(P<0.05),which increased in the treatment group compared with the control group(P<0.05).TCB in groups was decreased(P<0.05),which was decreased in the treatment group relevant to the control group(P<0.05).TBiL,TBA,IL-6,PCT,CysC in groups were decreased(P<0.05),the reduction in the treatment group was more common compared with the control group(P<0.05).Conclusion For neonatal pathological jaundice(internal retention of damp-heat syndrome),Jianganle granules has definite curative effect,can effectively reduce bilirubin level,protect nervous system development,inhibit inflammatory response,prevent complications and reduce adverse reactions.

关 键 词：新生儿黄疸 病理性 中药疗法 湿热内蕴 

分 类 号：R256.41[医药卫生—中医内科学]