DAZL基因多态性位点(A260G、A386G)与亚洲和高加索男性不育关系的meta分析  

Metar analysis of the correlation between DAZL gene polymorphisns sites(A260G and A386G)of men in Asia and Cauca-sus and their infertility

作　　者：周青 刘帅妹 张瑞金 李孟兰 林宁 封婕 黄丽丽 吴玉璘 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;LI Menglan;LIN Ning;FENG Jie;HUANG Lili;WU Yulin(Jiangu Health Deuvelopmen Research Cenuer,National Health and Family Plarning Com mission Contraceptives Aduerse Reaction Survillance Center,Nanjing,Jiangsu Prouince,210036)

机构地区：[1]江苏省卫生健康发展研究中心,国家卫健委计划生育药具不良反应监测中心,南京210036

出　　处：《中国计划生育学杂志》2023年第4期744-750,共7页Chinese Journal of Family Planning

基　　金：江苏省卫生健康发展研究中心自主科研项目(JSHD2021066);江苏省科技厅项目“孕前妇女维生素精准检测在出生缺陷预防中的应用”(M2020101)。

摘　　要：目的:评估DAZL基因多态性位点A260G和A386G与亚洲和高加索男性不育的关系。方法:检索中英文数据库中国知网、万方、Pubmed等,搜索有关DAZL基因A260G和A386G位点多态性与亚洲和高加索男性不育关系的病例对照研究,从建库时间截止至2022年10月,对纳入的文献采用State11.0软件进行meta分析。结果:共纳入18项病例对照研究,关于DAZL基因A260G位点多态性与亚洲和高加索男性不育的研究共13项,纳入病例组3031例,对照组2029例;关于DAZL基因A386G位点多态性与亚洲和高加索男性不育的研究共16项,纳入病例组4987例,对照组4201例;两个位点5个比较模型结果未发现显著意义的关联,根据人种和基因分型方法的不同进行亚组分析结果发现,DAZL基因A386G位点在PCR-SSCP组别G比A(OR=10.42,95%CI 3.73~29.10,Ph=0.811)、GA比AA(OR=10.69,95%CI 3.80~30.08,Ph=0.885)、GA+GG比AA(OR=10.90,95%CI 3.88~30.66,Ph=0.855)存在显著意义的关联。结论:DAZL基因A260G位点多态性与亚洲和高加索男性不育不存在相关性,根据基因分型方法进行亚组分析发现在PCR-SSCP组A386G位点多态性与亚洲和高加索男性不育存在相关性。Objective:To evaluate the correlation between DAZL gene polymorphisms sites(A260G and A386G)of men in Asia and Caucasus and their infertility.Methods:The Chinese and English databases.such as CNKI,Wan-fang,Pubmed,and s0 on were searched for the case-control studies about the correlation between DAZL gene poly-morphisms sites(A260G and A386G)of men in Asia and Caucasus and their itrility.Statel1.0 software was used for meta-analysis of the included literatures in the database from the establishment to October 2022.Results:A total of 18 cease-control studies were retrieved,including 13 studies about the correlation between DAZL gene polytnorphism site A260G of men in Asia and Caucasus and their inferility(3031 men in case group and 2029 men in control group),and 16 studies about the correlation between DAZL gene polymorphism site A386G of men in Asia and Caucasus and their infertility(4987 men in case group and 4201 men in controD).No significant as80ciation was found in the results of the five comparative models between sive A260G and site A386G.According to the race and genotyping methods.sub-group analysis showed that in the A386G site of DAZL.gene in PCR-SSCP group,there were significant associations between G and A(OR=10.42.95%CI 3.73-29.10,Ph=0.811).between GA and AA(OR=10.69.95%CI 3.80-30.08,Ph-0.885)。and between GA+GG and AA(OR=10.90,95%CI 3.88-30.66.Ph=0.855).Conclusion:The A260G site polymorphism of DAZL.gene of the men in Asia and Caucasus has no correlation with their infertility.According to the genotyping methods,subgroup analysis finds that A386G site polymorphism of DAZL gene in PCR-SSCP group of the men in Asia and Caucasus is correlated with their infertility.

关 键 词：DAZL 基因多态性 男性不育 META分析 

分 类 号：R698.2[医药卫生—泌尿科学]