中重度宫腔粘连组织中SDF-1、CXCR4的表达  

Expression levels of stromal cell-derived factor-1 and chemokine receptor 4 in moderate and severe intrauterine adhesions tissues of patients

作　　者：丁文 马丽丽[1] 贺笑茜 DING Wen;MA Lili;HE Xiaoqian(Daxing District People's Hospital,Beijing.102600)

机构地区：[1]北京市大兴区人民医院,102600

出　　处：《中国计划生育学杂志》2023年第4期889-893,共5页Chinese Journal of Family Planning

摘　　要：目的:探究中重度宫腔粘连(IUA)组织中基质细胞衍生因子-1(SDF-1)、趋化因子受体4(CXCR4)表达。方法:选取2019年4月-2022年4月本院确诊IUA中重度并行宫腔镜手术治疗的患者132例为IUA组,其中中度51例、重度81例;经宫腔镜确诊子宫纵隔患者132例为对照组,收集2组一般资料及性激素指标,免疫组化测定组织中SDF-1、CXCR4蛋白表达,Kaplan-Meier分析SDF-1、CXCR4表达与手术预后的关系;多因素Cox回归分析影响预后因素。结果:IUA组妊娠次数、分娩次数及妊娠相关宫腔手术次数均多于对照组,SDF-1阳性率(81.1%)高于对照组(25.0%),CXCR4阳性率(77.3%)高于对照组(20.5%),且重度IUA患者SDF-1阳性率(90.1%)、CXCR4阳性率(87.7%)高于中度IUA患者(66.7%、60.8%)(均P<0.05)。治疗无效者中SDF-1阳性表达患者占比(29.0%)高于阴性表达患者(12.0%),CXCR4阳性表达患者占比(31.4%)高于阴性表达患者(6.7%)(均P<0.001)。Cox回归分析,SDF-1、CXCR4是IUA患者预后的独立危险因素(P<0.05)。结论:IUA患者粘连组织中SDF-1、CXCR4阳性率提高,且与IUA患者病情严重程度及预后均有关。Obieetive:To investigate the expression levels of stromal ellderived factor-1(SDF-1)and chemokine te ceptor 4(CXCR4)in moderate and severe intrauterine adhesions(IUA)tssues of patients.Methods:From April 2019 to April 2022,132 patients with moderate and severe IUA diagnosed in hospital who wanted hysteroscopie surgery were selected in study group.including 51 patients with moderate in group A and 81 patients with severe patients in group B.Another 132 patients with uterine mediastinum diagnosed by hysteroscopy were selected in control group dur ing the same period.The general data and sex hormones indexes of all the patients were collected.The expression levels of SDF-1 and CXCR4 proteins of all the patients were detected by immunohistochemistry.Kaplan-Meier was used to analye the correlation between the exressions of SDF-1 and CXCR4 levels of the patients with IUA and their progno-sis after operation.Multivariate Cox regression was used to analyze the influence factors of the prognosis of IUA.Re-sults:The numbers of the pregnancy,delivery.and pregnancy-related uterine operation of the patients in the study group were significantly more than those of the patients in the control group.The positive rates of SDF-1(81.1%)and CXCR4(77.3%)of the patients in the study group were significantly higher than those(25.0%and 20.5%)of the pa-tients in the control group.The positive rates of SDF-1(90.1%)and CXCR4(87.7%)of the patients in group B were significantly higher than those(66.7% and 60.8%)of the petients in group A(all P<0.05).In the patients with fail treatment,the proportions of the positive exression of SDF-1(29.0%)and CXCR4(31.49%)of the patients were sig nificantly higher than those(12.0% and 6.7%)of the negative expression of SDF-1 and CXCR4 of the patients(all P<0.001).Cox regression analysis showed that the SDF-1 and CXCR4 levels of the patients with IUA were the independent risk factors of their prognosis of IUA(P<0.05).Conclusion:The positive rates of SDF-1 and CXCR4 in the IUA tssues of the patients increase

关 键 词：中重度宫腔粘连 粘连组织 基质细胞衍生因子-1 趋化因子受体4 预后 危险因素 

分 类 号：R711.74[医药卫生—妇产科学]