血清β-hCG、IL-6、ALP预测先兆性流产临床效果  

Clinical value of the combined detections of serum B human chorionic gonadotropin,interleukin-6,and alkaline phospha-tase of pregnant women for predicting their threatened abortion

作　　者：张杨[1] 罗玉萍 成文俊[1] ZHANG Yang;LUO Yuping;CHENG Wenjun(Luzhou People's Hospital,Luzhou,Sichuan Province,646000)

机构地区：[1]四川省泸州市人民医院,646000

出　　处：《中国计划生育学杂志》2023年第4期894-897,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨血清β-人绒毛膜促性腺激素(β-hCG)、白介素-6(IL-6)、碱性磷酸酶(ALP)预测先兆性流产的临床价值。方法:收集2019年1月-2020年1月本院接受规律产前检查被确诊为先兆性流产孕妇82例作为研究对象,均常规对症治疗;产前检查正常孕妇82例作为对照组。检测所有孕妇血清β-hCG、IL-6、ALP水平,记录先兆流产孕妇妊娠结局,采用受试者工作特征曲线(ROC)评价3指标对先兆性流产和流产结局的预测价值。结果:先兆流产组血清β-hCG、ALP水平低于对照组,IL-6水平高于对照组;82例先兆流产孕妇经治疗后,继续妊娠59例、流产23例;继续妊娠孕妇血清β-hCG、ALP水平、高于发生流产孕妇,IL-6水平低于发生流产孕妇(均P<0.05)。血清β-hCG、IL-6、ALP及其联合检测预测先兆流产的曲线下面积(AUC)分别为0.768、0.797、0.771、0.909,预测先兆流产结局的AUC分别为0.724、0.771、0.739、0.907(P<0.05)。结论:血清β-hCG、IL-6、ALP水平变化能预测先兆性流产的发生及其妊娠结局,且3项联合检测能提高诊断效能。Objective:To explore the clinical value of combined detections of serum β-human chorionic gonadotropin(β-hCG),interleukin-6(IL-6),and alkaline phosphatase(ALP)of pregnant women for predicting their threatened abor-tion.Methods:A total of 82 pregnant women who received regular antenatal examinations and were diagnosed with threatened abortion were selected in research group from January 2019 to January 2020.All the pregnant women were treated with conventional symptomatic treatment.Another 82 pregnant women with normal antenatal examination were selected in control group during the same period.The serum β-hCG,IL-6,and ALP levels of the women in the two groups were detected.The pregnancy outcomes of the women in the research group were recorded.Receiver oPerating characteristic(ROC)curve was used to evaluate the diagnostic value of the combined levels of serum β-hCG,IL-6,and.ALP of the women for the occurrence and the outcomes of their threatened abortion.Results:The levels of serum β-hCG and ALP of the women in the research group were significantly lower than those of the women in the control group,while the level of IL-6 of the women in the research group was significantly higher.Among 82 pregnant women with threatened abortion,59 cases continued pregnancy and there were 23 cases with abortion after treatment.The lev-els of serum β-hCG and ALP of the women with continued pregnancy were significantly higher than those of the women with abortion,and the level of IL-6 of the women with continued pregnancy was significantly lower(all P<0.05).The area under curve(AUC)of the serum p:hCG level,IL-6 level,ALP level,and the combined levels of serum β-hCG and ALP of the women for predicting the occurrence of their threatened abortion were 0.768,0.797,0.771,and 0.909,respectively,and the AUC of which for predicting the outcomes of their threatened abortion were 0.724,0.771,0.739,and 0.907,respec-tively(P<0.05).Conclusion:The changes of the serum β-hCG level,IL-6 level,and ALP level of the pregnant women.can predict

关 键 词：先兆性流产 人绒毛膜促性腺激素 白介素-6 碱性磷酸酶 预测 

分 类 号：R714.21[医药卫生—妇产科学]