孕晚期血清irisin、RBP-4与妊娠期高血压病情关系及对妊娠结局影响  

Correlation between the levels of serum irisin and retinol binding protein 4 of pregnant women during the third trimester of pregnancy and the severity of their pregnancy induced hypertension and their influence on the pregnancy outcomes

作　　者：李雪 王梦梅 杨红梅 LI Xue;WANG Mengmei;YANG Hongmei(The Second Hospital of Baoding,Baoding,Hebei Province,071051)

机构地区：[1]河北省保定市第二医院,071051

出　　处：《中国计划生育学杂志》2023年第4期927-931,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨孕晚期血清鸢尾素(irisin)、视黄醇结合蛋白-4(RBP-4)与妊娠期高血压孕妇病情的关系及不良妊娠结局。方法:选择2021年3月-2022年3月本院妇产科治疗的妊娠期高血压孕妇120例作为观察组,根据病情分为轻度组37例、中度组50例、重度组33例,产前检查正常孕妇60例为对照组。采用酶联免疫吸附法检测两组血清irisin、RBP-4水平,采用Pearson相关分析irisin、RBP-4与妊娠期高血压孕妇病情关系,比较不同irisin、RBP-4水平孕妇妊娠结局,采用多因素logistic回归分析妊娠期高血压妊娠不良结局影响因素。结果:观察组血清irisin(254.60±28.74 ng/L)低于对照组(552.44±56.66 ng/L),RBP-4(42.25±5.22μg/ml)高于对照组(23.36±3.26μg/ml),且重度组、中度组、轻度组血清irisin水平依次升高,血清RBP-4水平依次降低(均P<0.05)。Pearson相关分析显示,孕晚期血清irisin水平与妊娠期高血压病情严重程度呈负相关(r=-0.441,P<0.05),RBP-4水平与妊娠期高血压病情严重程度呈正相关(r=0.366,P<0.05)。妊娠期高血压孕妇中,irisin>254.60ng/L孕妇不良妊娠结局发生率低于irisin≤254.60ng/L孕妇,RBP-4>42.25μg/ml孕妇的不良妊娠结局发生率高于RBP-4≤42.25μg/ml孕妇(均P<0.05)。孕晚期血清irisin、RBP-4水平以及年龄均为影响妊娠期高血压孕妇妊娠结局的危险因素(P<0.05)。结论:妊娠期高血压孕妇孕晚期血清irisin水平降低、RBP-4水平升高,且二者水平与疾病的病情程度有关,与不良妊娠结局发生有关,提示临床参考评估。Objective:To explore the correlation between the levels of serum irisin and retinol binding protein 4(RBP 4)of pregnant women during the third trimester of pregnancy and the severity of their pregnancy induced hypertension(PIH),and to study the influence of levels of serum irisin and RBP 4 of the women with PIH on their pregnancy out-comes.Methods:From March 2021 to March 2022,120 pregnant women with PIH were selected in study group,and according to the severity of their PIH,these women were divided into group A(37 cases with mild PIH),group B(50 cases with moderate PIH),and group C(33 cases with severe PIH).In addition,60 normal pregnant women were se-lected in control group during the same period.The serum levels of irisin and RBP 4 of all the women were detected by enzyme linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between the levels of irisin and RBP 4 of the women and the severity of their PIH.The pregnancy outcomes were compared among the women with different levels of irisin and RBP 4.Multivariate logistic regression analysis was used to analyze the factors affecting adverse pregnancy outcomes of the women with PIH.Results:The serum irisin level(254.60±28.74 ng/L)of the women in the study group was significantly lower than that(552.44±56.66 ng/L)of the women in the control group,and the RBP 4 level(42.25±5.22 mu g/ml)of the women in the study group was significantly higher than that(23.36±3.26 mu g/ml)of the women in the control group.The serum irisin level of the women in group A,in group C,and in group B had increased gradually,and the RBP 4 level of the women in group A,in group C,and in group B had decreased gradually(all P<0.05).Pearson correlation analysis showed that the level of serum irisin of the women during the third trimester of pregnancy was negatively correlated with the severity of their PIH(r=0.441,P<0.05),and the serum RBP 4 level of the women during the third trimester of pregnancy was positively correlated with the se-verity of their P

关 键 词：孕晚期 妊娠期高血压 病情程度 鸢尾素 视黄醇结合蛋白-4 不良妊娠结局 

分 类 号：R714.246[医药卫生—妇产科学]