甘油三酯-葡萄糖指数对ACS患者冠状动脉病变严重程度及MACEs的预测价值  

Predictive value of triglyceride-glucose index on severity degree of coronary arterial lesion and MACEs in patients with ACS

作　　者：刘正阳 张月兰[1] LIU Zhengyang;ZHANG Yuelan(Department of Cardiology,First Affiliated Hospital of China Medical University,Shenyang,Liaoning 110000,China)

机构地区：[1]中国医科大学附属第一医院心内科,辽宁沈阳110000

出　　处：《重庆医学》2023年第8期1141-1146,共6页Chongqing medicine

基　　金：国家科技部重点研发计划项目(2018YFC1312400)。

摘　　要：目的探讨甘油三酯-葡萄糖指数(TyG)与急性冠状动脉综合征(ACS)患者冠状动脉病变严重程度的关系,分析其对病变严重程度及心血管结局的预测价值。方法纳入442例行冠状动脉介入治疗的ACS患者,随访20个月,依据TyG分为低TyG组(<9.0)和高TyG组(≥9.0)。分析不同TyG组患者基线资料间的关系。logistic回归模型评估TyG与冠状动脉病变SYNTAX评分间的相关性。ROC曲线、Cox风险比例模型分别评价TyG与冠状动脉病变SYNTAX评分和主要心脑血管不良事件(MACEs)的相关性。结果多因素logistic回归模型表明高TyG组SYNTAX评分较低TyG组增加[OR=3.09,95%CI(1.88,5.07),P<0.05]。ROC曲线证实TyG对ACS患者SYNTAX评分及MACEs具有诊断价值[AUC=0.62,95%CI(0.54,0.67),P<0.05;AUC=0.66,95%CI(0.60,0.71),P<0.05]。Cox风险比例模型表明TyG是MACEs的独立预测因子[HR=2.03,95%CI(1.29,3.17),P<0.05]。结论TyG越高冠状动脉病变越严重、MACEs发生率越高。Objective To investigate the relationship between triglyceride-glucose index(TyG)and the severity degree of lesions in the patients with acute coronary syndrome(ACS),and to analyze its predictive value for the severity degree of lesions and cardiovascular outcomes.Methods A total of 442 included patients with ACS patients undergoing the coronary intervention therapy were followed up for 20 months,and divided into the low TyG group(<9.0)and high TyG group(≥9.0)according to TyG.The relationship between baseline data of different TyG groups was analyzed.The Logistic regression model was used to assess the correlation between TyG and SYNTAX scores of coronary arterial lesion.The receiver operating characteristic(ROC)curve and Cox proportional hazards model were used to evaluate the correlation between TyG with SYNTAX score and major adverse cardiovascular events(MACEs),respectively.Results The multivariate Logistic regression model showed that the SYNTAX score in the high TyG group was increased compared with the low TyG group[OR=3.09,95%CI(1.88,5.07),P<0.05].The ROC curve confirmed that TyG had the diagnostic value on SYNTAX score and MACEs[AUC=0.62,95%CI(0.54,0.67),P<0.05;ACU=0.66,95%CI(0.60,0.71),P<0.05].The Cox hazards proportional model showed that TyG was an independent predictive factor of MACEs[HR=2.03,95%CI(1.29,3.17),P<0.05].Conclusion The higher the TyG,the more severe the coronary artery lesion and the higher the incidence rate of MACEs.

关 键 词：急性冠脉综合征 甘油三酯-葡萄糖指数 代谢综合征 SYNTAX评分 主要心脑血管不良事件 

分 类 号：R543[医药卫生—心血管疾病]