尿L-FABP、IGFBP-7在2型糖尿病并发早期急性肾衰竭患者中的表达及临床意义  

Expression and clinical significance of urinary L-FABP and IGFBP-7 in pat ients with type 2 diabetes complicated with early acute renal failure

作　　者：郭洋洋 GUO Yangyang(Department of Nephrology,The Fourth People’s Hospital of Langfang,Lang fang Hebei 065700)

机构地区：[1]河北省廊坊市第四人民医院肾内科,河北廊坊065700

出　　处：《当代医药论丛》2023年第8期1-5,共5页

摘　　要：目的:探讨尿肝型脂肪酸结合蛋白(L-FABP)、胰岛素样生长因子结合蛋白-7(IGFBP-7)在2型糖尿病(T2DM)并发早期急性肾衰竭患者中的表达及临床意义。方法:对2020年5月至2022年5月期间廊坊市第四人民医院收治的46例T2DM并发早期急性肾衰竭患者的临床资料进行回顾性分析,将其纳入发生组;另收集同期收治的46例T2DM无急性肾衰竭患者的临床资料,将其纳入未发生组。查阅两组患者的相关基线资料及临床资料,观察尿L-FABP、IGFBP-7在T2DM并发早期急性肾衰竭患者中的表达情况,分析尿L-FABP、IGFBP-7与T2DM患者早期急性肾衰竭的关系,并绘制受试者工作特征(ROC)曲线分析尿L-FABP、IGFBP-7对T2DM患者早期急性肾衰竭的诊断价值。结果:两组患者的性别、年龄、体质指数、长期饮酒史、T2DM病程、空腹血糖值、收缩压、舒张压以及白蛋白(ALB)、总蛋白(TP)水平比较,差异无统计学意义(P>0.05);发生组的尿L-FABP、IGFBP-7及血肌酐(Scr)水平均高于未发生组,差异有统计学意义(P<0.05)。经Logistic回归分析显示,尿L-FABP、IGFBP-7及Scr高表达是导致T2DM患者发生早期急性肾衰竭的危险因素(OR>1,P<0.05);绘制ROC曲线进行分析,结果显示尿L-FABP、IGFBP-7单项及联合检测诊断T2DM患者早期急性肾衰竭的曲线下面积(AUC)均>0.7,具有一定的诊断价值,且联合诊断价值较高。结论:尿L-FABP、IGFBP-7水平与T2DM患者的早期急性肾衰竭有关,二者在T2DM并发早期急性肾衰竭患者中表达升高,可作为诊断T2DM患者早期急性肾衰竭的重要参考指标。Objective:To investigate the expression and clinical significance of urinary liver fatty acid binding protein(L-FABP)and insulin-like growth factor binding protein-7(IGFBP-7)in patients with type 2 diabetes mellitus(T2DM)complicated with early acute renal failure.Methods:The clinical data of 46 patients with T2DM complicated with early acute renal failure admitted to the Fourth People’s Hospital of Langfang from May 2020 to May 2022 were retrospectively analyzed and included in the occurrence group.Clinical data of 46 T2DM patients without acute renal failure were also collected and included in the group without acute renal failure.The relevant baseline and clinical data of the two groups were consulted to observe the expression of urinary L-FABP and IGFBP-7 in patients with T2DM complicated with early acute renal failure,and to analyze the relationship between urinary L-FABP and IGFBP-7 and early acute renal failure in patients with T2DM.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of urinary L-FABP and IGFBP-7 in early acute renal failure in patients with T2DM.Results:There were no significant differences in gender,age,body mass index,long-term drinking history,course of T2DM,fasting blood glucose,systolic blood pressure,diastolic blood pressure and albumin(ALB)and total protein(TP)levels between 2 groups(P>0.05).Urinary L-FABP,IGFBP-7 and serum creatinine(Scr)levels in the occurrence group were higher than those in the non-occurrence group,with statistical significance(P<0.05).Logistic regression analysis showed that the high expression of urinary L-FABP,IGFBP-7 and Scr were risk factors for early acute renal failure in T2DM patients(OR>1,P<0.05).ROC curve was drawn for analysis,and the results showed that the area under the curve(AUC)of urinary L-FABP and IGFBP-7 in the diagnosis of early acute renal failure in T2DM patients were both>0.7,which had certain diagnostic value,and the combined diagnosis value was high.Conclusions:Urinary L-FABP and IGFBP-7 levels are a

关 键 词：2型糖尿病 急性肾衰竭 肝型脂肪酸结合蛋白 胰岛素样生长因子结合蛋白7 血肌酐 

分 类 号：R446[医药卫生—诊断学]