丹红注射液对慢性阻塞性肺疾病急性发作期患者血凝状态及免疫功能的影响  

Effect of Danhong Injection on coagulation status and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：喻承伟 贺燕 吴军 何芳志 YU Chengwei;HE Yan;WU Jun;HE Fangzhi(Department of Respiratory and Critical Care Medicine,Pingxiang No.2 People's Hospital,Jiangxi Province,Pingxiang337000,China)

机构地区：[1]江西省萍乡市第二人民医院呼吸与危重症医学科,江西萍乡337000

出　　处：《中国当代医药》2023年第12期58-61,共4页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2022B489)。

摘　　要：目的探讨丹红注射液改善慢性阻塞性肺疾病急性发作期(AECOPD)患者凝血状态及免疫功能的效果。方法选取2021年1月至2022年7月萍乡市第二人民医院收治的60例AECOPD患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组各30例。对照组患者采用常规AECOPD临床治疗,观察组患者在对照组的基础上加用丹红注射液治疗。比较两组患者的疗效及治疗前后的肺功能[第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、血流变指标[血浆及全血黏度、D-二聚体、血细胞比容(PCV)]、免疫功能[免疫球蛋白(IgA、IgG、IgM)、补体C3、补体C4]水平。结果观察组患者的临床疗效优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的FEV_(1)、FVC、FEV_(1)/FVC及免疫蛋白IgA、IgG、IgM高于治疗前,血浆及全血黏度、PCV、D-二聚体、补体C3、C4低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的FEV_(1)、FVC、FEV_(1)/FVC、免疫蛋白IgA、IgG、IgM高于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的血浆及全血黏度、PCV、D-二聚体、补体C3、C4低于对照组,差异有统计学意义(P<0.05)。结论丹红注射液可有效改善AECOPD患者的凝血状态和免疫功能,对提升治疗效果及改善患者预后有积极意义。Objective To explore the effect of Danhong Injection on coagulation status and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 60 patients with AECOP who were treated in Pingxiang No.2 People's Hospital from January 2021 and July 2022 were selected as the research subjects and were divided into observation group and control group according to the random number table method,with 30 cases in each group.The patients in the control group were given conventional AECOPD clinical treatment while the patients in observation group were additionally treated with Danhong Injection based on the treatment in the control group.The efficacy,pulmonary function(forced expiratory volume in one second[FEV_(1)],forced vital capacity[FVC],FEV_(1)/FVC),hemorheological indicators(plasma viscosity,whole blood viscosity,D-dimer,packed cell volume[PCV])and immune function(immunoglobulins[Ig]A,IgG,IgM,complement C3,complement C4)were compared between the two groups before and after treatment.Results After treatment,the clinical efficacy in observation group was better than that in control group,and the difference was statistically significant(P<0.05).The FEV_(1),FVC,FEV_(1)/FVC and immunoglobulins IgA,IgG and IgM after treatment in the two groups of patients were higher than those before treatment while the plasma viscosity,whole blood viscosity,PCV,D-dimer and complements C3 and C4 were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the FEV_(1),FVC,FEV_(1)/FVC and immunoglobulins IgA,IgG and IgM in observation group were higher than those in control group,the differences were statistically significant(P<0.05).The plasma viscosity,whole blood viscosity,PCV,D-dimer and complements C3 and C4 after treatment in observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion Danhong Injection can effectively improve the coagulation status and immune function

关 键 词：慢性阻塞性肺疾病 急性发作 凝血状态 免疫功能 丹红注射液 

分 类 号：R563.9[医药卫生—呼吸系统]