系统性红斑狼疮SLEDAI评分、血清补体与血压的相关性研究  

Study on the correlation between SLEDAI score,serum complement,and blood pressure in systemic lupus erythematosus

作　　者：陈惠媛 李爱娣 陈娟娟[1] CHEN Huiyuan;LI Aidi;CHEN Juanjuan(The second affiliated hospital of Nanchang University,"Jiangxi,Nanchang 330006)

机构地区：[1]南昌大学第二附属医院检验科,江西南昌330006

出　　处：《实验与检验医学》2023年第1期6-9,16,共5页Experimental and Laboratory Medicine

基　　金：国家自然科学基金,编号81960497;江西省自然科学基金,编号20181BA215026;江西省卫健委课题,编号20201061。

摘　　要：目的探讨系统性红斑狼疮(Systemic lupus erythematosus,SLE)初诊患者入院血压与系统性红斑狼疮活动指数(Systematic lupus erythematosus disease activity index,SLEDAI)评分、血清补体C3、C4的相关性,并评估引发SLE患者高血压的危险因素。方法2017年9月至2019年9月我院收治的95例SLE初诊患者,根据血压高低分为SLE血压升高组33例,SLE血压正常组62例,另选取同期100例健康体检者为对照组。采用医用臂式电子血压计测量3组入院血压;采用速率散射比浊法测定血清补体C3、C4;采用SLEDAI-2000评分评估SLE疾病活动程度;采用Pearson相关性分析法分析血压与实验指标的相关性,Logistic回归分析模型分析疾病危险因素。结果SLE初诊患者入院血压高于健康体检者。SLE血压升高组SLEDAI-2000评分显著高于SLE血压正常组。SLE初诊患者收缩压、舒张压与SLEDAI-2000评分呈正向相关关系(r=0.490,P<0.05;r=0.408,P<0.05),舒张压与血清补体C3、C4呈正向相关关系(r=0.223,P<0.05;r=0.285,P<0.05)。Logistic回归分析显示SLEDAI-2000评分和血清补体C3是导致SLE患者高血压的危险因素(P<0.05)。结论SLE初诊患者SLEDAI-2000评分与血压呈正向相关关系,舒张压与血清补体C3、C4呈正向相关关系。SLEDAI评分及血清补体C3是导致SLE患者高血压的危险因素。Objective To investigate the correlation between admission blood pressure and systemic lupus erythematosus disease activity index(SLEDAI)score,serum complement C3 and C4 levels in newly diagnosed patients with SLE and to evaluate the risk factors that trigger hypertension in SLE patients.Methods 95 SLE newly diagnosed patients in our hospital from September 2017 to September 2019 were divided into SLE blood pressure increasing group(n=33)and SLE blood pressure normal group(n=62),according to the high blood pressure and low blood pressure,respectively,and another 100 healthy individuals from the same period were selected as the control group.Admission blood pressure of the 3 groups was measured using a medical arm electronic sphygmomanometer.Serum complement C3 and C4 were measured by rate scattering nephelometry.The SLEDAI-2000 score was used to assess the degree of SLE disease activity.Pearson correlation analysis was used to analyze the correlation between blood pressure and experimental indexes,and Logistic regression analysis model was used to analyze disease risk factors.Results Patients with newly diagnosed SLE had higher admission blood pressure than those with a health check-up.SLEDAI-2000 score was significantly higher in the SLE blood pressure increasing group than in the SLE normotensive group.Systolic blood pressure in patients with newly diagnosed SLE diastolic blood pressure was positively correlated with SLEDAI-2000 score(r=0.490,P<0.05;r=0.408,P<0.05),and diastolic blood pressure was positively correlated with serum complement C3 and C4(r=0.223,P<0.05;r=0.285,P<0.05).Logistic regression analysis revealed that SLEDAI-2000 score and serum complement C3 were risk factors for developing hypertension in SLE patients(P<0.05).Conclusions The SLEDAI-2000 score and blood pressure were positively correlated with each other in patients with newly diagnosed SLE,and the diastolic blood pressure was positively correlated with serum complement C3 and C4.The SLEDAI score and serum complement C3 are risk factors f

关 键 词：系统性红斑狼疮 高血压 血清补体C3 危险因素 

分 类 号：R593.24[医药卫生—内科学]