60岁及以上老年人血清丙氨酸转氨酶与高血压合并糖尿病患病的关联性分析  

Association between serum alanine aminotransferase and hypertension complicated with diabetes in elderly aged 60years and above

作　　者：卢双艳 普惠婕 毛勇 陈洁 李梦启 张梅 周佳 王松梅 叶爱芳 Lu Shuangyan;Pu Huijie;Mao Yong;Chen Jie;Li Mengqi;Zhang Mei;Zhou Jia;Wang Songmei;Ye Aifang(School of Public Health,Kunming Medical University,Kunming650500,Yunnan Province,China)

机构地区：[1]昆明医科大学公共卫生学院,650500 [2]云南省安宁市中医医院健康管理中心

出　　处：《中华老年心脑血管病杂志》2023年第4期377-380,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：昆明医科大学老龄化健康管理科技创新团队建设项目(CXTD202103);云南省科学技术厅-昆明医科大学运用基础研究联合专项基金资助项目[2019FE001(-013)]。

摘　　要：目的探析年龄≥60岁老年人群血清丙氨酸转氨酶(ALT)水平与高血压合并糖尿病患病的关联性。方法选择2021年5月至2021年11月云南省安宁市76个自然村的年龄≥60岁老年人11794例,其中血清ALT>40 U/L老年人1080例,血清ALT≤40 U/L老年人10714例,依据基线血清ALT的四分位数将受试对象分为Q_(1)组3386例、Q_(2)组2632例、Q_(3)组2933例、Q4组2843例,采用多因素logistic回归模型分析血清ALT水平与高血压合并糖尿病患病的关联性。结果基线ALT>40 U/L的人群高血压合并糖尿病患病率明显高于ALT≤40 U/L人群,差异有统计学意义(P<0.01)。与Q_(1)组和Q_(2)组比较,Q4组的BMI、腰围、舒张压、收缩压、尿酸、TG、TC、天冬氨酸转氨酶、总胆红素、间接胆红素、空腹血糖明显升高,年龄、HDL-C明显降低,差异有统计学意义(P<0.05,P<0.01)。多因素logistic回归分析显示,血清ALT升高是血压合并糖尿病患病的危险因素(OR=1.302,95%CI:1.019~1.662,P=0.035)。结论年龄≥60岁老年人血清ALT增高与高血压合并糖尿病患病呈正相关关系,血清ALT水平升高可能是高血压合并糖尿病患病的危险因素。应加强对年龄≥60岁老年高血压或糖尿病患者血清ALT水平的管理。Objective To investigate the correlation between serum alanine aminotransferase(ALT)level and hypertension complicated with diabetes in the population aged 60years and above.Methods A total of 11794elderly patients aged≥60years from 76villages in Anning,Yunnan Province from May 2021to November 2021were selected.There were 1080elderly patients with serum ALT>40U/L and 10714elderly patients with serum ALT≤40U/L.According to the baseline serum ALT quartile,the subjects were divided into 3386cases in group Q_(1),2632cases in group Q_(2),2933cases in group Q_(3)and 2843cases in group Q4.Multivariate logistic regression model was used to analyze the correlation between serum ALT level and hypertension combined with diabetes.Results The prevalence of hypertension and diabetes was significantly higher in the baseline ALT>40U/L group than the baseline ALT≤40U/L group(P<0.01).Compared with groups Q_(1)and Q_(2),BMI,waist circumference,diastolic blood pressure,systolic blood pressure,uric acid,TG,TC,AST,total bilirubin,direct bilirubin,indirect bilirubin and fasting blood glucose in group Q4 were significantly increased(P<0.05,P<0.01),and age was younger(P<0.05,P<0.01).Multivariate logistic regression analysis showed that elevated serum ALT was a risk factor for blood pressure combined with diabetes(OR=1.302,95%CI:1.019-1.662,P=0.035).Conclusion The increase of serum ALT is positively correlated with hypertension and diabetes in the elderly aged 60years and above,and the increase of serum ALT level may be a risk factor for hypertension and diabetes.The management of serum ALT level in patients over 60years old with hypertension or diabetes should be strengthened.

关 键 词：高血压 糖尿病 丙氨酸转氨酶 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病] R587.2[医药卫生—内科学]