个体化阿托品治疗急性有机磷农药中毒的效果及血清髓过氧化物酶与胆碱酯酶、肌酸激酶水平的相关性  

Effect of individualized atropine on acute organophosphorus pesticide poisoning and correlation of serum myeloperoxidase with cholinesterase and creatine kinase

作　　者：陈康杰 陈粤明[1] 张丽平 苏耿[1] 王畅 CHEN Kang-jie;CHEN Yue-ming;ZHAGN Li-ping;SU Geng;WANG Chang(Department of Emergency Medicine,Zhanjiang Central People’s Hospital,Zhanjiang 524037,China)

机构地区：[1]湛江中心人民医院急诊医学科,广东湛江524037

出　　处：《广东医科大学学报》2023年第2期200-202,共3页Journal of Guangdong Medical University

基　　金：2020年湛江市科技计划项目(2020B01347)。

摘　　要：目的观察个体化阿托品治疗急性有机磷农药中毒(AOPP)的效果及血清髓过氧化物酶(MPO)与胆碱酯酶(ChE)、肌酸激酶(CK)水平的相关性。方法84例AOPP患者随机分为个体化和足量阿托品组,比较两组疗效及血清MPO、ChE、CK、乳酸脱氢酶(LDH)、心肌肌钙蛋白(cTnI)、C反应蛋白(CRP)的变化,分析MPO与ChE、CK的相关性。结果个体化组疗效优于足量组(P<0.05);治疗后两组血清MPO、ChE、CK、LDH、cTnI、CRP较治疗前有明显改善(P<0.01),其中个体化组MPO、ChE、CK改善更显著(P<0.01)。MPO与ChE呈正相关(r=0.68,P<0.05),与CK呈负相关(r=-0.11,P<0.05)。结论个体化阿托品治疗AOPP比足量阿托品治疗更具优势,MPO可作为判定AOPP恢复的指标之一。Objective To observe the effect of individualized atropine on acute organophosphorus pesticide poisoning(AOPP)and the correlation of serum myeloperoxidase(MPO)with cholinesterase(ChE)and creatine kinase(CK).Methods Eighty-four AOPP patients were randomly divided into individualized and sufficient atropine groups.Clinical efficacy and serum levels of MPO,ChE,CK,lactate dehydrogenase(LDH),cardiac troponin I(cTnI),and C-reactive protein(CRP)were compared between two groups.The correlation of MPO with ChE and CK was analyzed.Results Clinical effect of individualized group was better than that of sufficient group(P<0.05).Serum levels of MPO,ChE,CK,LDH,cTnI and CRP in two groups were ameliorated after treatment(P<0.01),with the obvious improvement of MPO,ChE and CK in individualized group(P<0.01).MPO was positively correlated with ChE(r=0.68,P<0.05),but negatively with CK(r=-0.11,P<0.05).Conclusion Individualized atropine efficacy is superior to sufficient atropine in AOPP.MPO may serve as one of the indicators to judge the recovery of AOPP.

关 键 词：急性有机磷农药中毒 阿托品 髓过氧化物酶 胆碱酯酶 

分 类 号：R595.4[医药卫生—内科学]