超声波法提取砂珍棘豆中盐酸小檗碱的工艺及优化  

Study and optimization of ultrasonic extraction technology of berberine hydrochloride from Oxytropis racemosa

作　　者：白小慧[1] 邢艳[1] 杜芳艳[1] 宋小利[1] 贺志春 BAI Xiaohui;XING Yan;DU Fangyan;SONG Xiaoli;HE Zhichun(School of Chemistry and Chemical Engineering,Yulin University,Yulin 719000,China)

机构地区：[1]榆林学院化学与化工学院,陕西榆林719000

出　　处：《化工科技》2022年第6期31-35,共5页Science & Technology in Chemical Industry

基　　金：中国科学院大学-榆林学院联合基金项目(2021003,2021006);陕西省科技厅项目(2020QFY05-05);榆林市科技计划项目(2019-83-3,2019-83-5,CXY-2020-012-11);榆林市高新区科技局项目(CXY-2020-031,CXY-2021-22);陕西省低变质煤洁净利用重点实验室项目(21JS047)。

摘　　要：研究了超声波提取法对砂珍棘豆中盐酸小檗碱提取率的影响,并以提取率作为评价指标。通过调控提取温度、提取时间、溶剂浓度、液料比,得出了最佳提取工艺,利用响应面法对实验结果进行了优化。优化结果表明,超声时间为30 min、超声温度为60℃、V(乙醇)∶m(砂珍棘豆)=30∶1 mL/g、φ(乙醇)=85%,砂珍棘豆中的盐酸小檗碱提取率最高,为6.426 mg/g。In this paper,the effects of ultrasonic extraction on the extraction rate of berberine in Oxytropis racemosa were studied,and the extraction rate was used as evaluation index by adjusting the extraction temperature,extraction time,solvent concentration and liquid-solid ratio,the optimal extraction process was obtained.Then,the experimental results were optimized by response surface methodology.The results showed that when the ultrasonic time was 30 min,the ultrasonic temperature was 60℃,the liquid-solid ratio was 30∶1 and the ethanol concentration was 85%,the extraction rate of berberine was the highest,which was 6.426 mg/g.

关 键 词：砂珍棘豆 盐酸小檗碱 超声提取法 响应面法 

分 类 号：O657.1[理学—分析化学]