糖尿病肾病中足细胞损伤机制的研究进展  

Research Progress on Mechanism of Podocyte Injury in Diabetic Nephropathy

作　　者：康文武 唐倩 严江天 苏振宏 梁凤霞 Kang Wenwu;Tang Qian;Yan Jiangtian(College of Acupuncture-Moxibustion and Orthopedics-Traumatology,Hubei University of Chinese Medicine,Wuhan 430061,China)

机构地区：[1]湖北中医药大学针灸骨伤学院,武汉430061 [2]肾脏疾病发生与干预湖北省重点实验室,黄石435003

出　　处：《华中科技大学学报（医学版）》2023年第2期270-275,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金面上项目(No.81774420);肾脏疾病发生与干预湖北省重点实验室开放基金项目(No.SB202108)。

摘　　要：糖尿病肾病是终末期肾病的主要病因。肾小球滤过屏障损伤导致的高蛋白尿是糖尿病肾病的主要特征,而足细胞功能及其结构的完整性对于肾小球滤过屏障至关重要。造成足细胞损伤的因素复杂且相互串扰,该文从糖脂代谢异常、氧化应激、慢性炎症、自噬、表观遗传学变化等角度阐释糖尿病肾病中足细胞的损伤机制,以期为糖尿病肾病的发生发展机制探讨、治疗及预后预测奠定理论基础。Diabetic nephropathy is the main cause of end-stage renal disease.Hyperproteinuria caused by glomerular filtration barrier injury is the main feature of diabetic nephropathy,and integrity of podocyte function and structural is crucial for glomerular filtration barrier.The causes of podocyte injury are complex and interrelated.This article explains the mechanism of podocyte injury from the perspective of abnormal glucose and lipid metabolism,oxidative stress,chronic inflammation,autophagy and epigenetic changes,in order to lay a theoretical foundation for the pathogenesis,treatment and prediction of diabetic nephropathy.

关 键 词：糖尿病肾病 足细胞 肾小球滤过屏障 

分 类 号：R587.2[医药卫生—内分泌]