2型糖尿病患者营养状况与代谢综合征的关联性研究  

Relationship between nutritional status and metabolic syndrome in patients with type 2 diabetes

作　　者：陈杨梅 张雪梅 曹慧 杜希 张旭[1] 符静 林琳[1] Chen Yangmei;Zhang Xuemei;Cao Hui;Du Xi;Zhang Xu;Fu Jing;Lin Lin(Department of Endocrinology,Beijing Chao-yang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,北京100020

出　　处：《中国临床保健杂志》2023年第2期210-214,共5页Chinese Journal of Clinical Healthcare

基　　金：北京市朝阳区科技计划项目(CYSF2110)。

摘　　要：目的 分析2型糖尿病(T2DM)患者营养状况与代谢综合征(MS)的关联性。方法 纳入首都医科大学附属北京朝阳医院内分泌科2020年10月至2021年2月期间住院的299例T2DM患者,根据国际糖尿病联合会(IDF)的定义将患者分为合并MS组和未合并MS组,比较2组血清25-羟基维生素D[25(OH)D]、叶酸、维生素B12、同型半胱氨酸(Hcy)和血清钙离子水平的差异,采用logistic回归分析T2DM患者营养状况与MS发生风险的关联性,采用相关性分析营养状况与MS代谢指标的相关性。结果 合并MS的T2DM患者血清25(OH)D水平降低(P<0.05);其余营养素在2组间差异无统计学意义。logistic回归分析发现血清25(OH)D水平升高可降低T2DM患者MS发生风险(P<0.05),并呈线性关联。较高的25(OH)D水平是MS发生的独立保护因素。结论 在T2DM患者中,血清25(OH)D水平与MS的发生密切相关。Objective To analyze the association between nutritional status and metabolic syndrome(MS)in patients with type 2 diabetes mellitus(T2DM).Methods Two hundred and ninety-nine T2DM patients hospitalized in the Department of Endocrinology of Beijing Chaoyang Hospital affiliated to Capital Medical University from October 2020 to February 2021 were included.According to the definition of the International diabetes Federation(IDF),the patients were divided into the combined MS group and the non combined MS group,and the differences in serum 25 hydroxyvitamin D[25(OH)D],folic acid,vitamin B 12,homocysteine(Hcy)and serum calcium ion levels between the two groups were compared,logistic regression was used to analyze the correlation between the nutritional status of T2DM patients and the risk of MS,and correlation analysis was used to analyze the correlation between nutritional status and metabolic indicators of MS.Results Serum 25(OH)D levels were significantly lower in T2DM patients with MS(P<0.05).The remaining nutrients did not differ significantly between the two groups.Elevated serum 25(OH)D levels significantly reduced the risk of MS in T2DM patients(P<0.05).Conclusions In patients with T2DM,serum 25(OH)D levels are closely associated with the development of MS.

关 键 词：糖尿病 2型 营养状况 代谢综合征 25-羟维生素D 危险因素 

分 类 号：R587.2[医药卫生—内分泌] R589[医药卫生—内科学]