无过渡金属催化电化学诱导C(sp^(3))-H胺化制备2-苯甲酰喹唑啉-4(3H)-酮  

Electrochemically induced preparation of 2-benzoylquinazolin-4(3H)-ones via C(sp^(3))-H amination without transition metal catalyst

作　　者：杨欢 陈太平 YANG Huan;CHEN Tai-ping(College of Science,Xihua University,Chengdu 610039,China;Campus of Yibin,Xihua University,Yibin 644000,China)

机构地区：[1]西华大学理学院,四川成都610039 [2]西华大学宜宾校区党工委,四川宜宾644000

出　　处：《化学研究与应用》2023年第4期878-883,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21401163)资助。

摘　　要：本研究建立了一种在无金属条件下,2-氨基苯甲酰胺与苯乙酮类化合物在单质碘(I_(2))催化下的电化学C(sp^(3))-H胺化制备2-苯甲酰喹唑啉-4(3H)-酮的反应。该反应以乙醇为溶剂,分子氧为理想的绿色氧化剂,在一个简单的未分裂电解池中进行,具有操作简便,无毒的特点,成本低廉,并且所有底物均能以较高的产率得到喹唑啉酮类衍生物,最高产率达88%。A simple and efficient electrochemical C(sp^(3))-H amination reaction of substituted 2-aminobenzamides and acetophenone compounds without transition metal catalyst for synthesizing 2-benzoylquinazolin-4(3H)-ones under the catalysis of iodine(I_(2))was studied in this research.The reaction proceeded using the relatively low-toxicity ethanol as the solvent,employed molecular oxygen as the ideal green oxidant in a simple undivided cell.The present methodology was operationally simple,non-toxic and varieties of compounds were obtained in high yields of up to 88%.

关 键 词：电化学 2-氨基苯甲酰胺 酮类化合物 2-苯甲酰喹唑啉-4(3H)-酮 

分 类 号：O621.3[理学—有机化学]