FLASH放射生物学机制及治疗计划研究进展  

Radiobiology and treatment plan progress of FLASH radiotherapy

作　　者：吴迅 刘锐锋 张秋宁 王小虎[1,2,3,4] WU Xun;LIU Ruifeng;ZHANG Qiuning;WANG Xiaohu(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;The First School of Clinical Medicine,Lanzhou University,Lanzhou 730000,China;Lanzhou Heavy Ion Hospital,Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]兰州大学第一临床医学院,兰州730000 [3]兰州重离子医院,兰州730000 [4]中国科学院大学,北京100049

出　　处：《辐射研究与辐射工艺学报》2023年第2期1-10,共10页Journal of Radiation Research and Radiation Processing

基　　金：甘肃省科技厅重点研发计划项目(20YF8FA116);兰州市人才创新创业项目(2020-RC-113);兰州科近泰基新技术有限责任公司研发项目(1100090020)。

摘　　要：近年来,一项被称为FLASH放疗的新技术具有将辐射的治疗增益比推向一个新高度的潜力。FLASH放疗是一种以超高剂量率照射为主要特征的放疗技术,能显著减轻辐射对正常组织的损伤,同时保留辐射对肿瘤的杀伤能力。一方面,作为一种新兴的放疗技术,FLASH放疗的生物学机制尚未被阐明,这阻碍了其临床转化;另一方面,超高剂量率照射技术的临床应用也存在许多技术困难。本综述通过归纳FLASH放射生物学机制的研究进展,总结FLASH放疗治疗计划所面临的困难及可能的解决方案,旨在为后续FLASH放疗的临床转化提供参考。FLASH radiotherapy is a novel method that has the potential to improve the therapeutic gain ratio to a new level.FLASH radiotherapy technology is mainly characterized by irradiation at ultra-high dose rate,which can reduce radiation-induced injury to normal tissues during radiotherapy,while maintaining the ability of radiation damage to tumors.On the one hand,as a new radiotherapy technology,the radiobiological mechanisms of FLASH are unclear,which hinders its clinical transformation.On the other hand,there are many technical difficulties in the clinical application of ultra-high dose rate irradiation technology.This paper summarizes the research progress of radiobiological mechanisms underlying FLASH radiotherapy,as well as the challenges and possible solutions associated with FLASH radiotherapy treatment plans, to provide a reference for clinical translation of subsequentFLASH radiotherapy.

关 键 词：FLASH 超高剂量率 放疗 放射生物学 治疗计划 

分 类 号：R81[医药卫生—放射医学]