脂肪干细胞及细胞因子在皮肤放射性损伤修复中的研究进展  

Advances in the study of adipose stem cells and cytokines in the repair of radiation skin damage

作　　者：宁艳 甘慧敏 黄东琳 王溪月 胡啸昊 黎洪棉 NING Yan;GAN Huimin;HUANG Donglin;WANG Xiyue;HU Xiaohao;LI Hongmian(The First People's Hospital of Nanning,Nanning 530000,China;Guangxi Medical University,Nanning 530000,China;Guangxi Zhuang Autonomous Region People's Hospital,Nanning 530000,China)

机构地区：[1]南宁市第一人民医院,南宁530000 [2]广西医科大学,南宁530000 [3]广西壮族自治区人民医院,南宁530000

出　　处：《辐射研究与辐射工艺学报》2023年第2期11-22,共12页Journal of Radiation Research and Radiation Processing

摘　　要：本文就当前脂肪干细胞(Ddipose-derived stem cells,ADSCs)与富血小板纤维蛋白(Platelet-rich fibrin,PRF)治疗皮肤软组织放射性损伤的研究概况进行探讨。相对于传统的治疗方式,ADSCs与PRF对于改善皮肤放射性损伤具有独特的优势。放射会使皮肤受到氧化损伤并产生细胞凋亡,从而引起红斑水肿、湿性脱屑等组织病理学改变;而ADSCs的抗凋亡、旁分泌生长因子、抗瘢痕的功能可以针对皮肤放射性损伤机制,减轻放射性损伤创面炎症,提高微血管密度,同时促进创面再上皮化,从而有效地改善皮肤放射性损伤;PRF释放的高浓度生长因子可明显提高创面的愈合率,并且PRF的生物特性能进一步优化ADSCs修复损伤的作用。结合ADSCs联合PRF治疗皮肤放射性损伤的研究现状,对今后的实验研究和临床治疗方向进行展望。This article discusses the current research status of adipose-derived stem cells(ADSCs)and plateletrich fibrin(PRF)in the treatment of soft tissue radiation injury in the skin.ADSCs and PRF have unique advantages over conventional treatment modalities for improving cutaneous radiation injury.Radiation causes oxidative damage to skin and skin cells subsequently undergo apoptosis,which causes histopathological changes such as erythema edema and wet desquamation.The anti-apoptotic,paracrine growth factor and anti-scarring functions of ADSCs can concomitantly target the mechanism underlying skin radiation injury,reduce inflammation of radiation-injured wounds,increase microvascular density,and promote re-epithelialization of wounds,thereby effectively improving skin radiation injury.The high concentration of growth factors released from PRF can significantly increase the healing rate of wounds,and the biological properties of PRF can further optimize the activity of ADSCs in repairing skin damage. Future experimental research and clinical treatment directions may involve combining the currentresearch status of ADSCs with PRF in the treatment of cutaneous radiation injury.

关 键 词：皮肤放射性损伤 脂肪干细胞 富血小板纤维蛋白 损伤修复 抗瘢痕 

分 类 号：TL7[核科学技术—辐射防护及环境保护]