免疫检查点抑制剂致免疫性肌炎及周围神经病1例  

A case of immune myositis and peripheral neuropathy induced by immune checkpoint inhibitor

作　　者：徐添姿 王腾飞 刘艺欣 魏永长[1] Tian-Zi XU;Teng-Fei WANG;Yi-Xin LIU;Yong-Chang WEI(Department of Gastrointestinal Tumors Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院胃肠肿瘤放化疗科,武汉430071

出　　处：《数理医药学杂志》2023年第4期316-320,共5页Journal of Mathematical Medicine

摘　　要：本文分析了1例特瑞普利单抗致免疫性肌炎与周围神经病的晚期肝门部胆管癌患者的诊治过程,并结合免疫检查点抑制剂相关文献,对其临床特征和诊疗原则进行总结。在应用抗肿瘤免疫治疗时,临床医师需严密监测患者相关指标,警惕免疫相关不良反应的发生,以期早诊断和早干预。停用免疫治疗、使用糖皮质激素和/或免疫抑制剂治疗对免疫相关不良事件患者的预后至关重要。A retrospective analysis of the diagnosis and treatment of a patients with advanced perihilar cholangiocarcinoma with immunodeficiency and peripheral neuropathy induced by terbutaline was conducted,and clinical features and principles of diagnosis and treatment were summarized in combination with relevant literature on immune checkpoint inhibitors.In the application of antitumor immunotherapy,clinicians should closely monitor relevant indicators of the patients and be alert to the occurrence of immune-related adverse reactions so that early diagnosis and intervention can be made.The discontinuation of immunotherapy and the use of corticosteroids and/or immunosuppressant therapy are critical to the prognosis of patients with immune-related adverse events(irAEs).

关 键 词：免疫检查点抑制剂 免疫性肌炎 周围神经病 肝门部胆管癌 

分 类 号：R969.3[医药卫生—药理学]