环状RNA在心力衰竭中作用的研究进展  

Research Progress on the Role of Circular RNA in Heart Failure

作　　者：李琳[1] 周蕾[1] LI Lin;ZHOU Lei(Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院心血管内科,江苏省南京市210029

出　　处：《实用心脑肺血管病杂志》2023年第5期125-128,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：国家自然科学基金资助项目(81970723);伊犁州临床医学研究院研究基金项目(yl2021zd02)。

摘　　要：环状RNA是一种单链共价闭合的非编码RNA,在体内稳定存在,具有“海绵效应”,能够调节基因表达,参与转录,编码蛋白质。本文综述了环状RNA在心力衰竭中的作用,指出环状RNA可以通过影响心肌肥大、心肌纤维化、心肌细胞凋亡等病理机制而参与心力衰竭的发生、发展,其有望成为心力衰竭新的治疗靶点。Circular RNA is a single-stranded covalently closed non-coding RNA,which is stable in vivo and has a"sponge effect".It can regulate gene expression,participate in transcription,and code protein.This article reviews the role of cyclic RNA in heart failure,and points out that circular RNA can participate in the occurrence and development of heart failure by affecting the pathological mechanisms of cardiac hypertrophy,myocardial fibrosis,and myocardial apoptosis.It is expected to become a new therapeutic target for heart failure.

关 键 词：心力衰竭 RNA 环状 心肌肥大 心肌纤维化 细胞凋亡 

分 类 号：R541.62[医药卫生—心血管疾病]