规律产前检查子痫前期患者早期临床发病特点分析  

Analysis of early clinical characteristics of preeclampsia patients with regular prenatal examination

作　　者：王微 张峰 邵申昊 Wang Wei;Zhang Feng;Shao Shenhao(Department of Medical Genetics,Changzhou Maternal and Child Health Care Hospital,Changzhou 213000,China;Chronic noncommunicable diseases control Department,Changzhou Center for Disease Control and Prevention,Changzhou 213000,China)

机构地区：[1]常州市妇幼保健院医学遗传科,江苏常州213000 [2]常州市疾病预防控制中心慢性非传染病防制科,江苏常州213000

出　　处：《实用妇科内分泌电子杂志》2022年第34期18-21,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：常州市科技项目应用基础研究计划(编号CJ20220244)。

摘　　要：目的研究规律产前检查子痫前期患者早期临床发病特点。方法选取120例子癫前期患者,采用前瞻性队列分析法比较患者风险因素和临床特征。结果重度子痫前期患者过度体重增加合并低蛋白血症、过度体重增加合并血小板计数(PLT)下降趋势发生高于轻度子痫前期患者(P<0.05)。重度子痫前期患者诊断前PLT下降>40%比例25.00%高于轻度子癫前期患者的8.33%(P<0.05)。两组首发症状、血压升高、尿蛋白增加、达子痫诊断标准、终止妊娠、预警出现至症状出现及预警出现至达诊断标准比较,差异有统计学意义(P<0.05)。规律产检与常规产检患者达子痫诊断标准、预警出现至症状出现、预警出现至达诊断标准、症状出现至达诊断标准及期待治疗时间比较,差异有统计学意义(P<0.05)。结论通过加强产前检查,可显著降低重度子痫前期的发病率,提前发现临床症状,延缓疾病发展的时间。Objective To study the early clinical characteristics of preeclampsia patients with regular prenatal examination.Methods A prospective cohort analysis was used to compare the risk factors and clinical features of 120 pregnant women with preepilepsy.Results Excessive weight gain combined with hypoproteinemia and excessive weight gain combined with decreased platelet count(PET)in severe preeclampsia were higher than those in mild preeclampsia(P<0.05).PLT decreased by more than 40%in patients with severe preeclampsia(25.00%)than in patients with mild preeclampsia(8.33%)(P<0.05).There were statistically significant differences in the first symptom,elevated blood pressure,increased urinary protein,reaching diagnostic criteria for eclampsia,termination of pregnancy,onset of warning to symptoms,and onset of warning to reaching diagnostic criteria between the two groups(P<0.05).There were statistically significant differences between patients with regular and routine prenatal examinations in reaching the diagnostic criteria for eclampsia,the onset of warning to symptoms,the onset of warning to diagnosis criteria,the onset of symptoms to diagnosis criteria and the expected treatment time(P<0.05).Conclusion By strengthening prenatal examination,the incidence of severe preeclampsia can be significantly reduced,clinical symptoms can be detected in advance,and the time of disease development can be delayed.

关 键 词：子痫前期 发病特点 产前检查 

分 类 号：R714.244[医药卫生—妇产科学]