基于隐结构模型分析泌尿系结石中医证候特征及辨证规律  

Analysis of TCM Syndrome Characteristics and Differentiation Rules of Urinary System Stones Based on Hidden Structure Model

作　　者：苏智楷 李倩 周映霖 陈浩强 周建甫 SU Zhikai;LI Qian;ZHOU Yinglin;CHEN Haoqiang;ZHOU Jianfu(The Second Clinical School of Guangzhou University of Traditional Chinese Medicine,Guangzhou Guangdong China 510405;The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou Guangdong China 510006)

机构地区：[1]广州中医药大学第二临床医学院,广东广州510405 [2]广州中医药大学第二附属医院,广东广州510006

出　　处：《中医学报》2023年第5期1125-1130,共6页Acta Chinese Medicine

基　　金：广东省中医药局面上项目(20221170);广东省大学生创新创业训练计划省级资助项目(202210572093);广州中医药大学第二临床医学院学生科研创新创业基金项目(202217)。

摘　　要：目的:探讨泌尿系结石的中医证候特征和辨证规律。方法:以近30年来发表的临床研究文献为数据源,采用Lantern 5.0软件建立隐结构模型,并对挖掘结果进行隐类诠释及分析讨论。结果:共检索得到274篇文献,最终纳入符合条件的文献95篇,其中包含251条证候记录,涉及22种证型,最常见的是下焦湿热证、气滞血瘀证、肾虚湿热证;共描述101种症状或体征,常见腰痛、尿中带血、小便频数、小便淋漓涩痛;对出现频率≥20%的症状构建隐结构模型得到5个隐变量,10个隐类,5个综合聚类模型;综合聚类提示的病位有肾、膀胱、小肠、肝、脾、心6个;病性有实、热、寒、虚4个;病理因素有湿热、阳虚、血瘀、肾虚、气虚、气郁、阻络、阴虚8个;证型有湿热蕴结证、气滞血瘀证、肾气亏虚证、肾阳亏虚证、肾阴亏虚证。结论:基于文献的隐结构模型分析能很好地表征泌尿系结石的中医证候特征和辨证规律。Objective:To explore the traditional Chinese medicine syndrome characteristics and differentiation rules of urinary tract stones.Method:Using clinical research literature published in the past 30 years as the data source,a hidden structure model was established using Lantern 5.0 software,and the mining results were interpreted and analyzed using hidden class analysis.Result:A total of 274 articles were retrieved,and 95 eligible articles were ultimately included,including 251 syndrome records,involving 22 types of syndromes.The most common ones were the lower energizer dampness heat syndrome,qi stagnation and blood stasis syndrome,and kidney deficiency dampness heat syndrome;A total of 101 symptoms or signs are described,including common low back pain,bloody urine,frequent urination,and painful urination.A hidden structure model was constructed for symptoms with a frequency more than 20%and 5 hidden variables,10 hidden classes,and 5 comprehensive clustering models were obtained.The disease locations indicated by comprehensive clustering include Kidney,Bladder,Small Intestine,Liver,Spleen,and Heart;There are four types of diseases:excess,Heat,Cold,and deficiency;Pathological factors include Damp Heat,Yang deficiency,blood stasis,Kidney deficiency,Qi deficiency,Qi stagnation,obstruction of collaterals,and Yin deficiency;The syndrome types include Damp Heat accumulation syndrome,Qi stagnation and blood stasis syndrome,Kidney Qi deficiency syndrome,Kidney Yang deficiency syndrome,and Kidney Yin deficiency syndrome.Conclusion:The hidden structure model analysis based on literature can effectively characterize the traditional Chinese medicine syndrome characteristics and differentiation rules of urinary tract stones.

关 键 词：泌尿系结石 中医证候 辨证规律 隐结构模型 

分 类 号：R277.5[医药卫生—中医学]