颈动脉粥样硬化的危险因素研究  

Research of risk factors for carotid atherosclerosis

作　　者：王绵绵[1] 陈雅芳[2] 杨美丽[2] 林君 许清攻 林培贤[4] 林华丽 WANG Mianmian;CHEN Yafang;YANG Meili;LIN Jun;XU Qinggong;LIN Peixian;LIN Huali(Department of Clinical Laboratory,Anxi Hospital of Traditional Chinese Medicine,Fujian Province,Anxi362400,China;Department of Neurology,the Second Affiliated Hospital of Fujian Medical University,Fujian Province,Quanzhou362000,China;Department of Ultrasound,Anxi Hospital of Traditional Chinese Medicine,Fujian Province,Anxi362400,China;Department of Neurology,Anxi Hospital of Traditional Chinese Medicine,Fujian Province,Anxi362400,China)

机构地区：[1]福建省安溪县中医院检验科,福建安溪362400 [2]福建省福建医科大学附属第二医院神经内科,福建泉州362000 [3]福建省安溪县中医院超声科,福建安溪362400 [4]福建省安溪县中医院神经内科,福建安溪362400

出　　处：《中国当代医药》2023年第13期58-61,共4页China Modern Medicine

基　　金：福建省自然科学基金项目(2020J01226);福建省安溪县中医院院管课题(2021AZY007B)。

摘　　要：目的探讨颈动脉粥样硬化的危险因素。方法选取2021年9月至2022年10月于安溪县中医院完成颈部血管彩超检查的358例住院患者为研究对象,根据有无颈动脉粥样硬化分为无颈动脉粥样硬化组和有颈动脉粥样硬化组,其中颈动脉粥样硬化组220例,无颈动脉粥样硬化组138例。收集两组患者的临床资料,采用单因素和logistic回归分析颈动脉粥样硬化相关危险因素。结果单因素分析结果显示,颈动脉粥样硬化组与无颈动脉粥样硬化组的年龄、白蛋白、空腹血糖、糖化血红蛋白(HbA1c)、尿酸、高血压病、糖尿病、卒中比较,差异有统计学意义(P<0.05)。多因素分析结果显示,年龄(β=0.094,OR=1.098,95%CI=1.065~1.133)、高血压(β=1.174,OR=3.235,95%CI=1.785~5.862)、糖尿病(β=1.222,OR=3.393,95%CI=1.652~6.968)、HbA1c水平(β=1.126,OR=3.083,95%CI=1.091~8.712),是颈动脉粥样硬化的危险因素(P<0.05)。结论HbA1c水平、年龄、高血压、糖尿病是颈动脉粥样硬化的独立危险因素.Objective To investigate the risk factors for carotid atherosclerosis.Methods A total of 358 inpatients who completed cervical vascular color Doppler ultrasonography in Anxi County Hospital of Traditional Chinese Medicine from September 2021 to October 2022 were selected as research objects.According to whether they had carotid atherosclerosis,they were divided into two groups,non-carotid atherosclerosis group and carotid atherosclerosis group.There were 220 patients in the carotid atherosclerosis group,and 138 patients in the non-carotid atherosclerosis group.Clinical data of the two groups were collected,univariate and logistic regression were used to analyze the risk factors related to carotid atherosclerosis.Results Univariate analysis indicated that there were statistically significant differences in age,albumin,fasting blood glucose,glycosylated hemoglobin(HbA1c),uric acid,hypertension,diabetes and stroke between the carotid atherosclerosis group and the non-carotid atherosclerosis group(P<0.05).The results of multivariate analysis indicated that age(β=0.094,OR=1.098,95%CI=1.065-1.133),hypertension(β=1.174,OR=3.235,95%CI=1.785-5.862),diabetes(β=1.222,OR=3.393,95%CI=1.652-6.968),HbA1c level(β=1.126,OR=3.083,95%CI=1.091-8.712)were risk factors of carotid atherosclerosis(P<0.05).Conclusion HbA1c level,age,hypertension and diabetes mellitus are independent risk factors for carotid atherosclerosis.

关 键 词：糖化血红蛋白 动脉粥样硬化 危险因素 关系 

分 类 号：R543.5[医药卫生—心血管疾病]