吡咯生物碱相关肝窦阻塞综合征患者预后的影响因素分析  

Analysis of prognostic factors of patients with pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome

作　　者：丁燕玲 刘欣欣 马铭泽 任万华[1,2] DING Yanling;LIU Xinxin;MA Mingze;REN Wanhua(Shandong University,Jinan,Shandong 250100,China;Department of Infectious Diseases,Shandong Provincial Hospital,Jinan,Shandong 250021,China;Digestive Endoscopy Center,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China;Department of Infectious Diseases,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250021,China)

机构地区：[1]山东大学,山东济南250100 [2]山东省立医院感染性疾病科,山东济南250021 [3]山东第一医科大学附属省立医院<山东省立医院>消化内镜中心,山东济南250021 [4]山东第一医科大学附属省立医院<山东省立医院>感染性疾病科,山东济南250021

出　　处：《医药前沿》2023年第5期1-4,9,共5页Journal of Frontiers of Medicine

摘　　要：目的:探讨吡咯生物碱相关肝窦阻塞综合征(PA-HSOS)预后相关影响因素并构建预后模型。方法:选取2013年12月—2022年5月山东省立医院诊治的57例PA-HSOS患者。根据随访情况分为死亡组(n=17)和存活组(n=40),采用单因素和多因素Logistic回归分析用于确定影响预后的相关影响因素,并构建预后预测模型,将其与肝脏储备功能(CTP)评分、终末期肝病模型(MELD)评分相比较,评估其预测价值。结果:凝血酶原活动度(PTA)和血肌酐(CR)是影响预后的独立因素(P<0.05),PTA联合CR(PTA-CR)可用于预测PA-HSOS患者的临床结局。结论:PTA、CR为PA-HSOS患者短期预后的独立影响因素;根据PA-HSOS患者预后相关因素建立的PTA-CR模型拟合度较好,可用于临床早期识别潜在高危患者。Objective To explore the prognostic risk factors and establish a prognostic model for pyrrolizidine alkaloid-related hepatic sinusoidal obstruction syndrome(PA-HSOS).Methods The clinical data of 57 cases with PA-HSOS diagnosed and treated in Shandong Provincial Hospital from December 2013 to May 2022 were selected.According to the follow-up results,the patients were divided into death group(n=17)and survival group(n=40).Univariate and multivariate logistic regression analysis was used to determine prognostic factors,and a prognostic model was constructed.It was compared with Child-Turcotte-Pugh(CTP)and the MELD(Model for End-Stage Liver Disease)scores to evaluate its predictive value.Results Prothrombin activity(PTA)and serum creatinine(CR)were independent prognostic factors(P<0.05).PTA combined with CR(PTA-CR)can be used to predict the clinical outcome of patients with PA-HSOS.Conclusion PTA and CR are independent influencing factors for short-term prognosis in patients with PA-HSOS;The PTA-CR model established based on prognostic factors in patients with PA-HSOS has a good fit and can be used to identify potentially high-risk patients in the early clinical stage.

关 键 词：吡咯生物碱 肝窦阻塞综合征 预后 菊三七 

分 类 号：R442.8[医药卫生—诊断学]