不同程度尼古丁依赖者脑功能连接密度改变的功能磁共振成像研究  

Changes of functional connectivity density in different severity of nicotine addicts:A functional magnetic resonance imaging stud

作　　者：牛晓玉 张勇[1] 杨镇圭 张孟哲 高昕宇 汪卫建 程敬亮[1] NIU Xiaoyu;ZHANG Yong*;YANG Zhengui;ZHANG Mengzhe;GAO Xinyu;WANG Weijian;CHENG Jingliang(Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450002

出　　处：《磁共振成像》2023年第4期11-15,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省重点研发与推广专项(科技攻关)项目(编号:212102310712)。

摘　　要：目的 本研究采用功能连接密度(functional connectivity density, FCD)的方法探究尼古丁依赖者静息状态下共有的大脑功能改变,以及不同程度的尼古丁依赖者是否有更特异的脑功能协调性改变。材料与方法 对120例尼古丁依赖者(轻度尼古丁依赖组59例、重度尼古丁依赖组61例)和56例正常对照(对照组)行静息态磁共振扫描并计算FCD值,首先采用ANOVA分析进行三组间FCD的比较,然后进行事后分析研究两组间的差异。结果 相较于对照组,轻度尼古丁依赖组及重度尼古丁依赖组均表现出双侧距状裂周围皮层FCD的降低;相较于对照组,只有重度尼古丁依赖组表现出右侧楔叶FCD的降低(体素水平P<0.005,团块水平P<0.01,高斯随机场校正)。结论 不同程度的尼古丁依赖者存在与视觉注意网络相关的共同协调性改变,这些改变随着尼古丁依赖的进展持续存在;重度尼古丁依赖者存在其特有的异常神经活动区域。本研究为不同程度尼古丁依赖的潜在神经机制提供了新的见解。Objective:We aimed to use the functional connectivity density(FCD)method to investigate the common functional brain alterations in the resting state of nicotine addicts,and whether there were more specific brain changes in functional coordination in different severity of nicotine addicts.Materials and Methods:A total of 120 nicotine addicts(59 in the mild group and 61 in the severe group)and 56 normal controls underwent resting state magnetic resonance imaging scanning and FCD values were calculated.FCD values were compared among the three groups by ANOVA analysis,and then the differences between the two groups were studied by post-hoc analysis.Results:Compared with the control group,both the mild group and the severe group showed decreased FCD in the bilateral calcarine sulcus cortex;only the severe group showed decreased FCD in the right cuneus(voxel level P<0.005,mass level P<0.01,Gaussian random field adjusted).Conclusions:There were common coordination changes related to the visual attention network in different severity of nicotine addicts,and they persisted with the progression of nicotine dependence.In severe nicotine addicts,the specific brain region of abnormal neural activity was observed.These findings provided new insights into the underlying neural mechanisms of different severity nicotine addicts.

关 键 词：尼古丁依赖 物质成瘾 视觉注意网络 注意偏向 功能连接密度 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.6[医药卫生—诊断学]