线粒体相关内质网膜对线粒体功能的影响  

Effect of mitochondria-associated endoplasmic reticulum membranes on mitochondrial function

作　　者：孙照鑫 冯红[1] SUN Zhaoxin;FENG Hong(Tianjin Key Laboratory of Exercise Physiology and Sports Medicine,Tianjin University of Sport,Tianjin 301617,China)

机构地区：[1]天津体育学院天津市运动生理学与运动医学重点实验室,天津301617

出　　处：《自然杂志》2023年第2期127-138,共12页Chinese Journal of Nature

摘　　要：线粒体是一种具有半自主性的细胞器。生物体内的生物合成、呼吸、分泌及机械运动等全部细胞活动所需要的化学能都是由线粒体提供的。线粒体相关内质网膜(MAMs)是与线粒体紧密联系的脂筏样结构域,位于线粒体与内质网(ER)之间。MAMs不仅仅在结构上连接ER和线粒体,还富含多种连接和功能蛋白,因此MAMs必然会对ER和线粒体功能产生影响。文章综述了MAMs的结构、分子组成及其对线粒体功能的影响,主要集中在线粒体融合、线粒体分裂、线粒体自噬、线粒体能量代谢及线粒体活性氧生成等方面,以期为通过MAMs调控线粒体功能来改善相关疾病提供参考。Mitochondria are semi-autonomous organelles where the chemical energy required for all cellular activities including biosynthesis,respiration,secretion,and mechanical movement in living organisms which is supplied by mitochondria.Mitochondriaassociated endoplasmic reticulum membranes(MAMs)are lipid raft-like domains closely associated with mitochondria and located between mitochondria and endoplasmic reticulum(ER).MAMs not only structurally connect ER and mitochondria but also are enriched in a variety of linking and functional proteins,so MAMs must have an impact on ER and mitochondrial function.This review focuses on the structure and molecular composition of MAMs,and the effects of MAMs on mitochondrial function.The main focus was on mitochondrial fusion,mitochondrial fission,mitophagy,mitochondrial energy metabolism and mitochondrial reactive oxygen species production.It is hoped to provide a reference for researchers who can improve related diseases by regulating mitochondrial function through MAMs.

关 键 词：线粒体 线粒体相关内质网膜(MAMs) 细胞功能 

分 类 号：Q24[生物学—细胞生物学]