柴胡加桂枝龙骨牡蛎汤治疗中青年高血压合并睡眠障碍  

Observation on the curative effect of Chaihu plus Guizhi Longgu Muli decoction in the treatment of young and middle-aged adults with hypertension complicated with sleep disorders

作　　者：陈洋 郭泉滢 CHEN Yang;GUO Quanying(Henan Hospital of Integrated Traditional Chinese and Western Medicine,Zhengzhou 450000,China)

机构地区：[1]河南省中西医结合医院,郑州450000

出　　处：《吉林中医药》2023年第4期411-414,共4页Jilin Journal of Chinese Medicine

基　　金：河南省中医药青苗人才培养项目(豫中医科教[2018]35号)。

摘　　要：目的 观察柴胡加桂枝龙骨牡蛎汤治疗中青年高血压合并睡眠障碍的疗效。方法 选取2020年6月-2022年6月河南省中西医结合医院收治的75例中青年高血压合并睡眠障碍患者的病例资料进行回顾性分析,根据治疗方式分为对照组(n=38)和观察组(n=37)。其中,对照组患者采取苯磺酸左旋氨氯地平加佐匹克隆片方案,观察组患者在对照组的基础上给予柴胡加桂枝龙骨牡蛎汤治疗。结果 观察组临床疗效优于对照组(P <0.05);2组患者治疗后收缩压、舒张压、匹兹堡睡眠指数(PQSI)评分与治疗前比较均降低,且观察组低于对照组(P <0.05);治疗后,2组患者血清5-羟色胺(5-hydroxytryptamine,5-HT)水平均升高,且观察组高于对照组;P物质水平均降低,观察组低于对照组(P <0.05);观察组患者不良反应发生率低于对照组(P <0.05);结论 柴胡加桂枝龙骨牡蛎汤治疗中青年高血压合并睡眠障碍,可提高患者疗效,稳定血压,改善患者睡眠质量,并且降低不良反应发生率。Objective To observe the therapeutic eff ect of the Chaihu plus Guizhi Longgu Muli decoction in the treatment of young and middle-aged adults with hypertension complicated with sleep disorders.Methods The clinical data of the 75 young and middle-aged patients with hypertension complicated with sleep disorders in our hospital were retrospectively analyzed(from June 2020 to June 2022),and they were divided into a control group(n=38)and an observation group(n=37)according to their treatment methods.Among them,the patients in the control group were treated with levamlodipine besylate plus zopiclone tablets,while the patients in the observation group were treated with the Chaihu plus Guizhi Longgu Muli decoction on the basis of the control group.Results The clinical effi cacy of the observation group was better than that of the control group(P<0.05).After treatment,the scores of systolic blood pressure,diastolic blood pressure and Pittsburgh Sleep Quality Index(PSQI)of patients in both groups were decreased,and the observation group was lower than the control group(P<0.05).After treatment,the levels of serum 5-hydroxytryptamine(5-HT)in both groups were increased,and the observation group was higher than the control group,while the levels of substance P were both decreased,and the observation group was lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion In the treatment of young and middle-aged patients with hypertension complicated with sleep disorders,the Chaihu plus Guizhi Longgu Muli decoction can improve the effi cacy,stabilize blood pressure,improve sleep quality and reduce the incidence of adverse reactions.

关 键 词：中青年 高血压 睡眠障碍 柴胡加桂枝龙骨牡蛎汤 睡眠质量 

分 类 号：R544[医药卫生—心血管疾病]