重构本草——瓦楞子  

Reconstruction of Chinese materia medica--clam shell

作　　者：胡诗宛 沈梦菲 张湘苑 孙郡 张伟 HU Shiwan;SHEN Mengfei;ZHANG Xiangyuan;SUN Jun;ZHANG Wei(Institute of Metabolic Diseases,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Beijing University of Chinese Medicine,Beijing 100029,China;Changchun University of Chinese Medicine,Changchun 130117,China;Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国中医科学院广安门医院代谢病研究所,北京100053 [2]北京中医药大学,北京100029 [3]长春中医药大学,长春130117 [4]甘肃中医药大学基础医学院,兰州730000

出　　处：《吉林中医药》2023年第4期465-467,共3页Jilin Journal of Chinese Medicine

基　　金：中国科学院学部咨询评议项目(2021-ZW10-A-017);中国工程科技发展战略海南研究院咨询研究项目(22-HN-ZD-03)。

摘　　要：通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内的专家学者的认识及应用经验,经讨论确定:瓦楞子功效主要为消痰化瘀,软坚散结,制酸止痛;症靶为反酸;标靶为消化道溃疡、结节肿块;现代药理发现瓦楞子及其有效成分具有中和胃酸以保护胃黏膜、抗肿瘤、调节免疫、降血压等作用;本品无毒,孕妇和过敏体质者慎服;临床使用剂量为9~60 g,内服时当根据不同疾病,或同一疾病的不同阶段进行辨证使用,并积极探索瓦楞子用量与症靶、标靶的量效关系构建。Based on the investigation of ancient books and literature,the progress and achievements of modern research on traditional Chinese medicine,and the understanding and application experience of experts and scholars in the fi eld of clinical Chinese medicine and Chinese materia medica,it is concluded that clam shell has the following characteristics:Its eff ects are mainly to eliminate phlegm and blood stasis,soften and resolve hard masses,relieve stomach acids and pains.Its symptom target is acid regurgitation,while its biochemical indicator targets are gastrointestinal ulcer,nodules and lumps.Modern pharmacology has found that clam shell and its eff ective ingredients have the eff ects of neutralizing gastric acids to protect gastric mucosa,suppressing tumors,regulating the immune function,lowering blood pressure,etc.It is non-toxic yet should be taken with caution for pregnant women and people with allergic constitutions.Its clinical dosage range is 9-60 g.When taken orally,it should be used according to diff erent diseases or the diff erent stages of the same disease,and an eff ort should be made to actively explore the construction of the dose-effect relationship between its dosage and its symptom targets and biochemical indicator targets.

关 键 词：瓦楞子 症靶 标靶 反酸 消化道溃疡 结节 临床回归 

分 类 号：R281.3[医药卫生—中药学]