大鼠神经性勃起功能障碍模型在实验中的应用  

Application of Rat Model of Neurotic Erectile Dysfunction in Experiment

作　　者：胡轩韩 钱麟 魏海彬[2] 徐智慧[2] HU Xuanhan;QIAN Lin;WEI Haibin;XU Zhihui(The Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Urology,Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College,Hangzhou 310014,China)

机构地区：[1]浙江中医药大学第二临床医学院,杭州310053 [2]浙江省人民医院、杭州医学院附属人民医院泌尿外科,杭州310014

出　　处：《中国医学科学院学报》2023年第2期311-316,共6页Acta Academiae Medicinae Sinicae

基　　金：浙江省卫生健康科技计划项目(2021KY449)。

摘　　要：勃起功能障碍(ED)是指阴茎持续不能达到和/或维持足够的勃起以获得满意的性生活。ED对于患者及其性伴侣的生活质量会带来较大的影响。近些年来,为阐明ED的病理生理机制,多种ED动物模型应运而生,并取得了一系列的进展。啮齿类动物的海绵体神经(CN)在解剖上与人类相近,且具有性价比高、粗大易辨认等优势,逐渐成为ED动物模型的主流。本文回顾了近年来大鼠双侧CN损伤所致神经性ED动物模型的建立方式,总结了其模型的检测及评价指标,探讨了ED动物模型在基础实验研究当中的应用及进展。Erectile dysfunction(ED)refers to the persistent inability to achieve and/or maintain a sufficient erection of the penis to obtain a satisfactory sexual life,which affects the quality of life of the patients and their sexual partners.To decipher the pathophysiological mechanism of ED,researchers have established a variety of animal models and achieved a series of progress.The cavernous nerve(CN)of rodents,anatomically similar to that of humans,is cost-effective,thick,and easy to be identified,which has gradually become the mainstream of animal models.In this paper,we reviewed the modeling methods of the neurological ED caused by bilateral CN injury in rats in recent years,summarized the model evaluation indicators,and discussed the application and progress of ED models in basic experimental research.

关 键 词：海绵体神经损伤 勃起功能障碍 大鼠 动物模型 

分 类 号：R332[医药卫生—人体生理学]