胎盘组织抗氧化损伤因子表达预测未足月胎膜早破产妇宫内感染的价值  

Values of antioxidative injury factors in placental tissue in prediction of intrauterine infection in puerpera with preterm premature rupture of membranes

作　　者：黄菊[1] 黄素静 朱晶[3] 符浮 胡宏嫒 HUANG Ju;HUANG Su-jing;ZHU Jing;FU Fu;HU Hong-ai(Wanning People's Hospital,Hainan Province,Wanning,Hainan 571500,China;不详)

机构地区：[1]海南省万宁市人民医院产科,海南万宁571500 [2]海南医学院第二附属医院产科,海南海口570000 [3]海南省中医院妇科,海南海口570000 [4]海南省万宁市人民医院妇科,海南万宁571500

出　　处：《中华医院感染学杂志》2023年第5期776-780,共5页Chinese Journal of Nosocomiology

基　　金：海南省医药卫生科研基金资助项目(2009032054A2001)。

摘　　要：目的分析胎盘组织抗氧化损伤因子表达预测未足月胎膜早破(PPROM)产妇宫内感染的价值。方法选取2021年3月-2022年3月在海南省万宁市人民医院产科住院分娩的96例PPROM产妇为PPROM组,选取100例足月胎膜早破(TPROM)产妇为TPROM组,选取100名足月未发生胎膜早破产妇为对照组。对三组产妇的基础资料、宫内感染发生率及胎盘组织抗氧化损伤因子表达进行对比。结果PPROM组产妇的宫内感染发生率为29.17%(28/96),高于TPROM组和对照组(P<0.05)。PPROM组产妇胎盘组织核因子E2相关因子2(Nrf2)、血红素氧合酶1(HO-1)、醌NADH脱氢酶1(NQO1)表达阳性率均低于TPROM组或对照组(P<0.05),PPROM组产妇胎盘组织Nrf2、HO-1、NQO1相对表达量均低于TPROM组或对照组(P<0.05)。在PPROM组中,发生宫内感染产妇胎盘组织Nrf2、HO-1、NQO1表达强度等级、表达阳性率及相对表达量均低于未发生产生宫内感染产妇(P<0.05)。三种抗氧化损伤因子预测PPROM产妇宫内感染的受试者工作特征(ROC)曲线下面积(AUC)均有统计学意义(P<0.05),其中,Nrf2的AUC和敏感度最高,分别为0.907和72.06%。结论与TPROM产妇和正常足月产妇比较,PPROM产妇存在胎盘组织抗氧化损伤因子的表达下降,特别是合并宫内感染产妇的胎盘组织抗氧化损伤因子表达水平更低,可作为预测宫内感染风险的辅助指标。OBJECTIVE To analyze the values of antioxidative injury factors in placental tissue in prediction of intrauterine infection in puerpera with preterm premature rupture of membranes(PPROM).METHODS A total of 96 puerpera with PPROM who gave birth in obstetrics department of Wanning People′s Hospital,Hainan Province,from Mar 2021 to Mar 2022 were assigned as the PPROM group,100 puerpera with term premature rupture of membranes(TPROM)were chosen as the TPROM group,and 100 puerpera who had term delivery but did not have PROM were chosen as the control group.The baseline data,incidence of intrauterine infection and expression levels of placental tissue antioxidative injury factors were observed and compared among the three groups of puerpera.RESULTS The incidence of intrauterine infection of the PPROM group was 29.17%(28/96),higher than that of the TPROM group or the control group(P<0.05).The positive expression rates of placental tissue nuclear factor E2 related factor 2(Nrf2),hemeoxygenase-1(HO-1)and NADH:quinone dehydrogenase-1(NQO1)of the PPROM group were lower than those of the TPROM group or the control group(P<0.05),the relative expression levels of placental tissue Nrf2,HO-1 and NQO1 of the PPROM group were lower than those of the TPROM group or the control group(P<0.05).In the PPROM group,the expression intensity grade,positive expression rate and relative expression level of placental tissue Nrf2,HO-1 and NQO1 of the puerpera with intrauterine infection were lower than those of the puerpera without intrauterine infection(P<0.05).There was significant difference in the area under receiver operating characteristic(ROC)curve(AUC)in prediction of intrauterine infection among the three types of antioxidative injury factors(P<0.05);the AUC of Nrf2 was 0.907,and the sensitivity was 72.06%.CONCLUSION As compared with the puerpera with TPROM and the term delivery puerpera,the puerpera with PPROM have the declined expressions of antioxidative injury factors in placental tissue,and the puerpera who are complicated with

关 键 词：胎盘组织 抗氧化损伤因子 未足月 胎膜早破 产妇 宫内感染 预测价值 

分 类 号：R714.433[医药卫生—妇产科学]