高压氧辅助标准大骨瓣开颅术对重型颅脑损伤患者血流动力学及血清炎性因子的影响  

Effect of Hyperbaric Oxygen Assisted Standard Large Bone Flap Craniotomy on Hemodynamics and Serum Inflammatory Factors in Patients with Heavy Craniocerebral Injury

作　　者：杨超 管峥峰 雷鹏 YANG Chao;GUAN Zhengfeng;LEI Peng(Department of Brain Surgery,Liyang Hospital of Traditional Chinese Medicine,Liyang,Jiangsu Province,213300 China)

机构地区：[1]溧阳市中医医院脑外科,江苏溧阳213300

出　　处：《世界复合医学》2023年第1期130-133,共4页World Journal of Complex Medicine

摘　　要：目的 探讨对重型颅脑损伤患者采用高压氧辅助标准大骨瓣开颅术治疗后对其血清炎性因子以及血流动力学产生的影响。方法 选取2017年7月—2021年4月溧阳市中医医院收治的84例重型颅脑损伤患者,按照数字奇偶法分为治疗组和对照组,各42例。治疗组采用高压氧+标准大骨瓣开颅术方式完成颅脑损伤治疗,对照组采用常规骨瓣开颅术方式完成颅脑损伤治疗,比较两组的血清炎性因子水平以及血流动力学水平。结果 手术前,治疗组患者CRP(38.39±9.13)mg/L与对照组(38.52±9.15)mg/L比较,差异无统计学意义(P>0.05);手术后,治疗组CRP(11.49±4.52)mg/L低于对照组(22.49±6.25)mg/L,差异有统计学意义(t=9.242,P<0.05)。治疗组患者MTT(2.08±0.33)s、TTP(15.90±1.82)s均低于对照组MTT(3.59±0.51)s、TTP(20.05±1.25)s,治疗组CBF(33.31±8.05)mL/(100 g·min)以及CBV(2.26±0.49)m L/100 g均高于对照组CBF(22.26±7.35) mL/(100 g·min)以及CBV(1.12±0.32)mL/100 g,差异有统计学意义(t=16.109、12.181、6.569、12.624,P<0.05)。结论 高压氧+标准大骨瓣开颅术的有效应用,使得重型颅脑损伤患者血流动力学获得的稳定,炎症获得改善,从而促进重型颅脑损伤患者有效预后。Objective To explore the effects on serum inflammatory factors and hemodynamics in patients with heavy craniocerebral injury after treatment with hyperbaric oxygen-assisted standard large bone flap craniotomy.Methods 84 patients with severe craniocerebral injury admitted to Liyang Traditional Chinese Medicine Hospital from July 2017 to April 2021 were selected,and divide them into treatment group and control group according to the digital parity method,with 42 cases each.The treatment group was treated with hyperbaric oxygen+standard large bone flap craniotomy,while the control group was treated with conventional bone flap craniotomy.The levels of serum inflammatory factors and hemodynamics were compared between the two groups.Results Before operation,there was no statistically significant difference in CRP(38.39±9.13)mg/L between the treatment group and the control group(38.52±9.15)mg/L(P>0.05).After operation,the CRP in the treatment group was(11.49±4.52)mg/L lower than that in the control group(22.49±6.25)mg/L,the difference was statistically significant(t=9.242,P<0.05).The MTT(2.08±0.33)s and TTP(15.90±1.82)s of patients in the treatment group were lower than those in the control group(3.59±0.51)s and TTP(20.05±1.25)s,and the CBF(33.31±8.05)mL/(100 g·min)and CBV(2.26±0.49)mL/100 g in the treatment group were higher than those in the control group(22.26±7.35)mL/(100 g·min)and CBV(1.12±0.32)mL/100 g,the difference was statistically significant(t=16.109,12.181,6.569,12.624,P<0.05).Conclusion The effective application of hyperbaric oxygen+standard large bone flap craniotomy resulted in the stabilization of hemodynamics and improvement of inflammation in patients with heavy craniocerebral injury.So as to promote the effective prognosis of patients with severe craniocerebral injury.

关 键 词：高压氧 标准大骨瓣开颅术 重型颅脑损伤 血清炎性因子 血流动力学 

分 类 号：R4[医药卫生—临床医学]